English   español  
Por favor, use este identificador para citar o enlazar a este item: http://hdl.handle.net/10261/143478
Compartir / Impacto:
Estadísticas
Add this article to your Mendeley library MendeleyBASE
Citado 1 veces en Web of Knowledge®  |  Pub MebCentral Ver citas en PubMed Central  |  Ver citas en Google académico
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar otros formatos: Exportar EndNote (RIS)Exportar bibText (RIS)Exportar csv (RIS)
Título

Proteinaceous molecules mediating Bifidobacterium-host interactions

AutorRuíz García, Lorena ; Delgado, Susana ; Ruas-Madiedo, Patricia ; Margolles Barros, Abelardo ; Sánchez García, Borja
Palabras claveHost interaction
Adhesin
Immunomodulation
Proteome
Bifidobacterium
Fecha de publicación3-ago-2016
EditorFrontiers Media
CitaciónFrontiers in Microbiology 7: 1193 (2016)
ResumenBifidobacteria are commensal microoganisms found in the gastrointestinal tract. Several strains have been attributed beneficial traits at local and systemic levels, through pathogen exclusion or immune modulation, among other benefits. This has promoted a growing industrial and scientific interest in bifidobacteria as probiotic supplements. However, the molecular mechanisms mediating this cross-talk with the human host remain unknown. High-throughput technologies, from functional genomics to transcriptomics, proteomics, and interactomics coupled to the development of both in vitro and in vivo models to study the dynamics of the intestinal microbiota and their effects on host cells, have eased the identification of key molecules in these interactions. Numerous secreted or surface-associated proteins or peptides have been identified as potential mediators of bifidobacteria-host interactions and molecular cross-talk, directly participating in sensing environmental factors, promoting intestinal colonization, or mediating a dialogue with mucosa-associated immune cells. On the other hand, bifidobacteria induce the production of proteins in the intestine, by epithelial or immune cells, and other gut bacteria, which are key elements in orchestrating interactions among bifidobacteria, gut microbiota, and host cells. This review aims to give a comprehensive overview on proteinaceous molecules described and characterized to date, as mediators of the dynamic interplay between bifidobacteria and the human host, providing a framework to identify knowledge gaps and future research needs.
Versión del editorhttps://doi.org/10.3389/fmicb.2016.01193
URIhttp://hdl.handle.net/10261/143478
DOI10.3389/fmicb.2016.01193
Identificadoresissn: 1664-302X
Aparece en las colecciones: (IPLA) Artículos
Ficheros en este ítem:
Fichero Descripción Tamaño Formato  
Proteinaceous Molecules-Ruiz.pdf1,27 MBAdobe PDFVista previa
Visualizar/Abrir
Mostrar el registro completo
 



NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.