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Phage lytic proteins: Biotechnological applications beyond clinical antimicrobials

AuthorsRodríguez, Lorena ; Gutiérrez, Diana ; Donovan, David M.; Martínez Fernández, Beatriz ; Rodríguez González, Ana ; García Suárez, María Pilar
Pathogen detection
Virion-associated peptidoglycan hydrolases
Food safety
Issue Date2016
PublisherTaylor & Francis
CitationCritical Reviews in Biotechnology 36: 542-552 (2016)
AbstractMost bacteriophages encode two types of cell wall lytic proteins: endolysins (lysins) and virion-associated peptidoglycan hydrolases. Both enzymes have the ability to degrade the peptidoglycan of Gram-positive bacteria resulting in cell lysis when they are applied externally. Bacteriophage lytic proteins have a demonstrated potential in treating animal models of infectious diseases. There has also been an increase in the study of these lytic proteins for their application in areas such as food safety, pathogen detection/diagnosis, surfaces disinfection, vaccine development and nanotechnology. This review summarizes the more recent developments, outlines the full potential of these proteins to develop new biotechnological tools and discusses the feasibility of these proposals.
Publisher version (URL)https://doi.org/10.3109/07388551.2014.993587
Identifiersissn: 1549-7801
Appears in Collections:(IPLA) Artículos
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