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Title

Impact of prematurity and perinatal antibiotics on the developing intestinal microbiota: A functional inference study

AuthorsArboleya, Silvia ; Sánchez García, Borja ; Solís, Gonzalo; Fernández, Nuria; Suárez, Marta ; Hernández-Barranco, Ana María ; Margolles Barros, Abelardo ; González de los Reyes-Gavilán, Clara ; Gueimonde Fernández, Miguel
KeywordsAntibiotics
Infants
Preterm
Intestinal microbiota
Microbiome
Issue Date29-Apr-2016
PublisherMolecular Diversity Preservation International
CitationInternational Journal of Molecular Sciences 17: 649 (2016)
Abstract[Background] The microbial colonization of the neonatal gut provides a critical stimulus for normal maturation and development. This process of early microbiota establishment, known to be affected by several factors, constitutes an important determinant for later health.
[Methods] We studied the establishment of the microbiota in preterm and full-term infants and the impact of perinatal antibiotics upon this process in premature babies. To this end, 16S rRNA gene sequence-based microbiota assessment was performed at phylum level and functional inference analyses were conducted. Moreover, the levels of the main intestinal microbial metabolites, the short-chain fatty acids (SCFA) acetate, propionate and butyrate, were measured by Gas-Chromatography Flame ionization/Mass spectrometry detection.
[Results] Prematurity affects microbiota composition at phylum level, leading to increases of Proteobacteria and reduction of other intestinal microorganisms. Perinatal antibiotic use further affected the microbiota of the preterm infant. These changes involved a concomitant alteration in the levels of intestinal SCFA. Moreover, functional inference analyses allowed for identifying metabolic pathways potentially affected by prematurity and perinatal antibiotics use.
[Conclusion] A deficiency or delay in the establishment of normal microbiota function seems to be present in preterm infants. Perinatal antibiotic use, such as intrapartum prophylaxis, affected the early life microbiota establishment in preterm newborns, which may have consequences for later health.
Publisher version (URL)https://doi.org/10.3390/ijms17050649
URIhttp://hdl.handle.net/10261/143390
DOI10.3390/ijms17050649
Identifiersissn: 1422-0067
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