Por favor, use este identificador para citar o enlazar a este item:
http://hdl.handle.net/10261/143390
COMPARTIR / EXPORTAR:
SHARE CORE BASE | |
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
Título: | Impact of prematurity and perinatal antibiotics on the developing intestinal microbiota: A functional inference study |
Autor: | Arboleya, Silvia CSIC ORCID ; Sánchez García, Borja CSIC ORCID; Solís, Gonzalo; Fernández, Nuria; Suárez, Marta CSIC ORCID; Hernández-Barranco, Ana María CSIC; Margolles Barros, Abelardo CSIC ORCID; González de los Reyes-Gavilán, Clara CSIC ORCID ; Gueimonde Fernández, Miguel CSIC ORCID | Palabras clave: | Antibiotics Infants Preterm Intestinal microbiota Microbiome |
Fecha de publicación: | 29-abr-2016 | Editor: | Molecular Diversity Preservation International | Citación: | International Journal of Molecular Sciences 17: 649 (2016) | Resumen: | [Background] The microbial colonization of the neonatal gut provides a critical stimulus for
normal maturation and development. This process of early microbiota establishment, known to be
affected by several factors, constitutes an important determinant for later health. [Methods] We studied the establishment of the microbiota in preterm and full-term infants and the impact of perinatal antibiotics upon this process in premature babies. To this end, 16S rRNA gene sequence-based microbiota assessment was performed at phylum level and functional inference analyses were conducted. Moreover, the levels of the main intestinal microbial metabolites, the short-chain fatty acids (SCFA) acetate, propionate and butyrate, were measured by Gas-Chromatography Flame ionization/Mass spectrometry detection. [Results] Prematurity affects microbiota composition at phylum level, leading to increases of Proteobacteria and reduction of other intestinal microorganisms. Perinatal antibiotic use further affected the microbiota of the preterm infant. These changes involved a concomitant alteration in the levels of intestinal SCFA. Moreover, functional inference analyses allowed for identifying metabolic pathways potentially affected by prematurity and perinatal antibiotics use. [Conclusion] A deficiency or delay in the establishment of normal microbiota function seems to be present in preterm infants. Perinatal antibiotic use, such as intrapartum prophylaxis, affected the early life microbiota establishment in preterm newborns, which may have consequences for later health. |
Versión del editor: | https://doi.org/10.3390/ijms17050649 | URI: | http://hdl.handle.net/10261/143390 | DOI: | 10.3390/ijms17050649 | Identificadores: | issn: 1422-0067 |
Aparece en las colecciones: | (IPLA) Artículos |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
---|---|---|---|---|
Impact of prematurity-Arboleya.pdf | 587,41 kB | Unknown | Visualizar/Abrir |
CORE Recommender
PubMed Central
Citations
67
checked on 10-abr-2024
SCOPUSTM
Citations
110
checked on 16-abr-2024
WEB OF SCIENCETM
Citations
94
checked on 24-feb-2024
Page view(s)
296
checked on 19-abr-2024
Download(s)
266
checked on 19-abr-2024