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Title

Neurexin and neuroligin genes in Alzheimer's disease

AuthorsRuiz, Agustín; Martínez Mir, Amalia ; González-Pérez, Antonio; Gayán, Javier; Antúnez, Carmen; Marín, Juan J.; Boada, Mercè; López-Arrieta, Jesús; Fernández, Evaristo; Ramírez Lorca, Reposo; Sáez, María E.; Scholl, Francisco G.; Real, Luis Miguel
Issue DateMar-2013
Citation11th International Conference on Alzheimer's & Parkinson's Diseases (2013)
Abstract[Objectives] The interaction between neurexins and neuroligins promotes the formation of functional synaptic structures. Recently, it has been reported that neurexins and neuroligins are proteolytically processed by presenilins at synapses. Based on this interaction and the role of presenilins in familial Alzheimer's disease (AD), we hypothesized that dysfunction of the neuroligin-neurexin pathway might be associated with AD.
[Methods] To explore this hypothesis we carried out a meta-analysis of five genome-wide association studies (GWAS) comprising 1256 SNPs in the NRXN1, NRXN2, NRXN3 and NLGN1 genes (3009 cases and 3006 control individuals) using PLINK software.
[Results] We identified a marker in the NRXN3 gene (rs17757879) that showed a consistent protective effect in all GWAS, however the statistical significance obtained did not resist multiple testing corrections (OR=0.851, p=0.002). Nonetheless, gender analysis revealed that this effect was restricted to males. A replication study with SNP rs17757879 in a Spanish population (1785 cases and 1634 controls) confirmed this observation (OR=0.752, C.I.=0.570-0.991, p=0.042).
[Conclusions] We conclude that NRXN3 might have a role in susceptibility to AD in males (rs17757879, OR=0.742, 95% C.I.=0.632-0.872, p=0.00028, final meta-analysis).
DescriptionPóster presentado en la 11th International Conference on Alzheimer's & Parkinson's Diseases, celebrada en Florencia del 6 al 10 de marzo de 2013.-- Alzheimers Disease Neuroimaging Inititive
URIhttp://hdl.handle.net/10261/143273
Appears in Collections:(IBIS) Comunicaciones congresos
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