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Título: | The role of endoglin in post-ischemic revascularization |
Autor: | Núñez-Gómez, E.; Pericacho, Miguel CSIC ORCID CVN; Ollauri-Ibáñez, C.; Bernabéu, Carmelo CSIC ORCID ; López-Novoa, José M. | Palabras clave: | Angiogenesis Arterial occlusion Arteriogenesis Collateral growth Endoglin Ischemia Revascularization Vascular remodeling |
Fecha de publicación: | feb-2017 | Editor: | Springer Nature | Citación: | Angiogenesis 20(1):1-24 (2017) | Resumen: | Following arterial occlusion, blood vessels respond by forming a new network of functional capillaries (angiogenesis), by re-organizing pre-existing capillaries through the recruitment of smooth muscle cells to generate new arteries (arteriogenesis) and by growing and remodeling pre-existing collateral arterioles into physiologically relevant arteries (collateral development). All these processes result in the recovery of organ perfusion. The importance of endoglin in post-occlusion reperfusion is sustained by several observations: i) endoglin expression is increased in vessels showing active angiogenesis/remodeling; ii) genetic endoglin haploinsufficiency in humans causes deficient angiogenesis; and iii) the reduction of endoglin expression by gene disruption or the administration of endoglin-neutralizing antibodies reduces angiogenesis and revascularization. However, the precise role of endoglin in the several processes associated with revascularization has not been completely elucidated and, in some cases, the function ascribed to endoglin by different authors is controversial. The purpose of this review is to organize in a critical way the information available for the role of endoglin in several phenomena (angiogenesis, arteriogenesis, and collateral development) associated with post-ischemic revascularization. | Descripción: | 60 p.-5 fig.-1 tab. | Versión del editor: | http://dx.doi.org/10.1007/s10456-016-9535-4 | URI: | http://hdl.handle.net/10261/143256 | DOI: | 10.1007/s10456-016-9535-4 | ISSN: | 0969-6970 | E-ISSN: | 1573-7209 |
Aparece en las colecciones: | (CIB) Artículos |
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Angiogenesis_Núñez Gómez_2016pdf.pdf | Postprint | 1,73 MB | Adobe PDF | Visualizar/Abrir |
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