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| Title: | Icogenin, a new cytotoxic steroidal saponin isolated from Dracaena draco |
Authors: | Hernández, Juan C. CSIC; León, Francisco CSIC ORCID; Quintana, José; Estévez, Francisco; Bermejo, Jaime CSIC | Issue Date: | 26-Jun-2004 | Publisher: | Elsevier | Citation: | Bioorganic and Medicinal Chemistry Letters 12(16): 4423-4429 (2004) | Abstract: | This paper reports on the cytotoxic effect induced by a new natural steroidal saponin, icogenin, on the myeloid leukemia cell line HL-60. Icogenin was found to be a cytotoxic compound IC50 2.6 ± 0.9 μM at 72 h, with growth inhibition caused by the induction of apoptosis, as determined by microscopy of nuclear changes and the fragmentation of poly(ADP-ribose) polymerase-1. | Description: | 7 pages, 3 figures, 2 tables.-- PMID: 15265493 [PubMed].-- Printed version published Aug 15, 2004. | Publisher version (URL): | http://dx.doi.org/10.1016/j.bmc.2004.06.009 | URI: | http://hdl.handle.net/10261/14323 | DOI: | 10.1016/j.bmc.2004.06.009 | ISSN: | 0960-894X |
| Appears in Collections: | (IPNA) Artículos |
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