Please use this identifier to cite or link to this item:
http://hdl.handle.net/10261/14323Share/Export:
 SHARE
 CORE
BASE
|
|
| Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
| Title: | Icogenin, a new cytotoxic steroidal saponin isolated from Dracaena draco |
Authors: | Hernández, Juan C. CSIC; León, Francisco CSIC ORCID; Quintana, José; Estévez, Francisco; Bermejo, Jaime CSIC | Issue Date: | 26-Jun-2004 | Publisher: | Elsevier | Citation: | Bioorganic and Medicinal Chemistry Letters 12(16): 4423-4429 (2004) | Abstract: | This paper reports on the cytotoxic effect induced by a new natural steroidal saponin, icogenin, on the myeloid leukemia cell line HL-60. Icogenin was found to be a cytotoxic compound IC50 2.6 ± 0.9 μM at 72 h, with growth inhibition caused by the induction of apoptosis, as determined by microscopy of nuclear changes and the fragmentation of poly(ADP-ribose) polymerase-1. | Description: | 7 pages, 3 figures, 2 tables.-- PMID: 15265493 [PubMed].-- Printed version published Aug 15, 2004. | Publisher version (URL): | http://dx.doi.org/10.1016/j.bmc.2004.06.009 | URI: | http://hdl.handle.net/10261/14323 | DOI: | 10.1016/j.bmc.2004.06.009 | ISSN: | 0960-894X |
| Appears in Collections: | (IPNA) Artículos |
Show full item record
Review this work
SCOPUSTM
Citations
38
checked on May 16, 2022
WEB OF SCIENCETM
Citations
34
checked on May 17, 2022
Page view(s)
357
checked on May 21, 2022
Google ScholarTM
Check
Altmetric
Dimensions
WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.