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Icogenin, a new cytotoxic steroidal saponin isolated from Dracaena draco

AuthorsHernández, Juan C. ; León, Francisco ; Quintana, José; Estévez, Francisco; Bermejo, Jaime
Issue Date26-Jun-2004
CitationBioorganic and Medicinal Chemistry Letters 12(16): 4423-4429 (2004)
AbstractThis paper reports on the cytotoxic effect induced by a new natural steroidal saponin, icogenin, on the myeloid leukemia cell line HL-60. Icogenin was found to be a cytotoxic compound IC50 2.6 ± 0.9 μM at 72 h, with growth inhibition caused by the induction of apoptosis, as determined by microscopy of nuclear changes and the fragmentation of poly(ADP-ribose) polymerase-1.
Description7 pages, 3 figures, 2 tables.-- PMID: 15265493 [PubMed].-- Printed version published Aug 15, 2004.
Publisher version (URL)http://dx.doi.org/10.1016/j.bmc.2004.06.009
Appears in Collections:(IPNA) Artículos
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