English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/143109
Share/Impact:
Statistics
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:

Title

The effects of bifidobacterium breve on immune mediators and proteome of ht29 cells monolayers

AuthorsSánchez García, Borja ; González Rodríguez, Irene ; Arboleya, Silvia ; López, Patricia ; Suárez, Ana; Ruas-Madiedo, Patricia ; Margolles Barros, Abelardo ; Gueimonde Fernández, Miguel
Issue Date2015
PublisherHindawi Publishing Corporation
CitationBioMed Research International 2015: 479140 (2015)
AbstractThe use of beneficial microorganisms, the so-called probiotics, to improve human health is gaining popularity. However, not all of the probiotic strains trigger the same responses and they differ in their interaction with the host. In spite of the limited knowledge on mechanisms of action some of the probiotic effects seem to be exerted through maintenance of the gastrointestinal barrier function and modulation of the immune system. In the present work, we have addressed in vitro the response of the intestinal epithelial cell line HT29 to the strain Bifidobacterium breve IPLA20004. In the array of 84 genes involved in inflammation tested, the expression of 12 was modified by the bifidobacteria. The genes of chemokine CXCL6, the chemokine receptor CCR7, and, specially, the complement component C3 were upregulated. Indeed, HT29 cells cocultivated with B. breve produced significantly higher levels of protein C3a. The proteome of HT29 cells showed increased levels of cytokeratin-8 in the presence of B. breve. Altogether, it seems that B. breve IPLA20004 could favor the recruitment of innate immune cells to the mucosa reinforcing, as well as the physical barrier of the intestinal epithelium. © 2015 Borja Sánchez et al.
Publisher version (URL)https://doi.org/10.1155/2015/479140
URIhttp://hdl.handle.net/10261/143109
DOI10.1155/2015/479140
Identifiersissn: 2314-6141
Appears in Collections:(IPLA) Artículos
Files in This Item:
File Description SizeFormat 
Bifidobacterium breve-Sanchez.pdf1,16 MBAdobe PDFThumbnail
View/Open
Show full item record
Review this work
 

Related articles:


WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.