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Surface glycosaminoglycans protect eukaryotic cells against membrane-driven peptide bacteriocins

AuthorsMartín, Rebeca; Escobedo, Susana; Martín, Carla; Crespo, Ainara; Quirós, Luis M.; Suárez Fernández, Juan Evaristo
Issue DateJan-2015
PublisherAmerican Society for Microbiology
CitationAntimicrobial Agents and Chemotherapy 59(1): 677-681 (2015)
AbstractEnzymatic elimination of surface glycosaminoglycans or inhibition of their sulfation provokes sensitizing of HT-29 and HeLa cells toward the peptide bacteriocins nisin A, plantaricin C, and pediocin PA-1/AcH. The effect can be partially reversed by heparin, which also lowers the susceptibility of Lactococcus lactis to nisin A. These data indicate that the negative charge of the glycosaminoglycan sulfate residues binds the positively charged bacteriocins, thus protecting eukaryotic cells from plasma membrane damage. Copyright © 2015, American Society for Microbiology. All Rights Reserved.
Publisher version (URL)https://doi.org/10.1128/AAC.04427-14
Identifiersissn: 1098-6596
Appears in Collections:(IPLA) Artículos
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