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Title

Antifeedant C20 diterpene alkaloids

AuthorsGonzález-Coloma, Azucena ; Reina, Matías ; Guadaño, Ana; Martínez Díaz, Rafael; Díaz, Jesús G.; García Rodíguez, Juan; Alva, Allenger; Grandez, Maritza
Issue Date23-Sep-2004
PublisherJohn Wiley & Sons
CitationChemistry and Biodiversity 1(9): 1327-1335 (2004)
AbstractWe have tested the insect antifeedant and toxic activity of 21 C20 diterpenoid alkaloids on Spodoptera littoralis and Leptinotarsa decemlineata. The antifeedant effects of the test compounds were structure- and species-dependent. The most active antifeedants to L. decemlineata and S. littoralis were the rearranged form of hetisine (20; EC50=1.7 μg/cm2) and 19-oxodihydroatisine (9; EC50=0.1 μg/cm2), resp. Glandulosine (8) moderately affected orally injected S. littoralis larvae. A few compounds (13-oxocardiopetamine (4), 9, and atisinium chloride (13)) had cytotoxic effects to insect-derived Sf9 cells with varying degrees of selectivity with respect to mammalian CHO cells. Compounds 4 and 15,22-O-diacetyl-19-oxodihydroatisine (10) increased Trypanosoma cruzi mortality. Our results support the plant protective role of C20 diterpenoid alkaloids and open a new field for parasite control strategies.
Description9 figures, 3 figures, 2 tables.-- PMID: 17191910 [PubMed].
Publisher version (URL)http://dx.doi.org/10.1002/cbdv.200490095
URIhttp://hdl.handle.net/10261/14305
DOI10.1002/cbdv.200490095
ISSN1612-1872
Appears in Collections:(ICA) Artículos
(IPNA) Artículos
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