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Título: | Is256 abolishes gelatinase activity and biofilm formation in a mutant of the nosocomial pathogen enterococcus faecalis v583 |
Autor: | Pérez, Marta M.; Calles-Enríquez, Marina CSIC; Río Lagar, Beatriz del CSIC ORCID ; Ladero Losada, Víctor Manuel CSIC ORCID ; Martín, M. Cruz CSIC ORCID ; Fernández García, María CSIC ORCID ; Álvarez González, Miguel Ángel CSIC ORCID | Palabras clave: | Biofilms Gelatinase Insertion sequences Enterococcus faecalis |
Fecha de publicación: | 22-abr-2015 | Editor: | Canadian Science Publishing | Citación: | Canadian Journal of Microbiology 61(7): 517-519 (2015) | Resumen: | Enterococcus faecalis is one of the most controversial species of lactic acid bacteria. Some strains are used as probiotics, while others are associated with severe and life-threatening nosocomial infections. Their pathogenicity depends on the acqui-sition of multidrug resistance and virulence factors. Gelatinase, which is required in the first steps of biofilm formation, is an important virulence determinant involved in E. faecalis pathogenesis, including endocarditis and peritonitis. The gene that codes for gelatinase (gelE) is controlled by the Fsr quorum-sensing system, whose encoding genes (fsrA, fsrB, fsrC, and fsrD) are located immediately upstream of gelE. The integration of a DNA fragment into the fsr locus of a derived mutant of E. faecalis V583 suppressed the gelatinase activity and prevented biofilm formation. Sequence analysis indicated the presence of IS256 integrated into the fsrC gene at nucleotide position 321. Interestingly, IS256 is also associated with biofilm formation in Staphylococcus epidermidis and Staphylococcus aureus. This is the first description of an insertion sequence that prevents biofilm formation in E. faecalis. Copyright de NRC Research Press | Versión del editor: | https://doi.org/10.1139/cjm-2015-0090 | URI: | http://hdl.handle.net/10261/143039 | DOI: | 10.1139/cjm-2015-0090 | Identificadores: | issn: 1480-3275 |
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Abolishes Gelatinase Activity-Perez et al.pdf | 482,03 kB | Adobe PDF | Visualizar/Abrir |
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