Por favor, use este identificador para citar o enlazar a este item:
http://hdl.handle.net/10261/143008
COMPARTIR / EXPORTAR:
SHARE CORE BASE | |
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
Título: | Genetic modification of hypoxia signaling in animal models and its effect on cancer |
Autor: | García-Heredia, J. M.; Felipe-Abrio, Blanca CSIC ORCID; Cano González, David A. CSIC ORCID; Carnero, Amancio CSIC ORCID | Palabras clave: | Hipoxia Cáncer Genetically modified mouse models |
Fecha de publicación: | feb-2014 | Editor: | Springer Nature | Citación: | Clinical and Translational Oncology 17(2): 90-102 (2014) | Resumen: | © 2014, Federación de Sociedades Españolas de Oncología (FESEO). Conditions that cause hypoxemia or generalized tissue hypoxia, which can last for days, months, or even years, are very common in the human population and are among the leading causes of morbidity, disability, and mortality. Therefore, the molecular pathophysiology of hypoxia and its potential deleterious effects on human health are important issues at the forefront of biomedical research. Generalized hypoxia is a consequence of highly prevalent medical disorders that can severely reduce the capacity for O2 exchange between the air and pulmonary capillaries. In recent years, some of the key O2-dependent signaling pathways have been characterized at the molecular level. In particular, the prolyl hydroxylase (PHD)-hypoxia-inducible factor (HIF) cascade has emerged as the master regulator of a general gene expression program involved in cell/tissue/organ adaptation to hypoxia. Hypoxia has emerged as a critical factor in cancer because it can promote tumor initiation, progression, and resistance to therapy. Beyond its role in neovascularization as a mechanism of tumor adaptation to nutrient and O2 deprivation, hypoxia has been linked to prolonged cellular lifespan and immortalization, the generation of “oncometabolites”, deregulation of stem cell proliferation, and inflammation, among other tumor hallmarks. Hypoxia may contribute to cancer through several independent pathways, the inter-connections of which have yet to be elucidated. Furthermore, the relevance of chronic hypoxemia in the initiation and progression of cancer has not been studied in depth in the whole organism. Therefore, we explore here the contributions of hypoxia to the whole organism by reviewing studies on genetically modified mice with alterations in the key molecular factors regulating hypoxia. | Versión del editor: | http://doi.org/10.1007/s12094-014-1236-0 | URI: | http://hdl.handle.net/10261/143008 | DOI: | 10.1007/s12094-014-1236-0 | Identificadores: | e-issn: 1699-3055 issn: 1699-048X |
Aparece en las colecciones: | (IBIS) Artículos |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
---|---|---|---|---|
accesoRestringido.pdf | 15,38 kB | Adobe PDF | Visualizar/Abrir |
CORE Recommender
SCOPUSTM
Citations
10
checked on 12-abr-2024
WEB OF SCIENCETM
Citations
10
checked on 22-feb-2024
Page view(s)
290
checked on 18-abr-2024
Download(s)
101
checked on 18-abr-2024
Google ScholarTM
Check
Altmetric
Altmetric
NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.