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Title

Disruptive chemicals, senescence and immortality

AuthorsCarnero, Amancio ; Blanco-Aparicio, Carmen; Yasaei, Hemad
KeywordsMutation
Tumorigenesis
Elderly
Carcinogenesis
Cell aging
Carcinogens
Aging
Issue Date19-Jun-2015
PublisherOxford University Press
CitationCarcinogenesis 36(Suppl 1): S19-S37 (2015)
Abstract© The Author 2015. Carcinogenesis is thought to be a multistep process, with clonal evolution playing a central role in the process. Clonal evolution involves the repeated 'selection and succession' of rare variant cells that acquire a growth advantage over the remaining cell population through the acquisition of 'driver mutations' enabling a selective advantage in a particular micro-environment. Clonal selection is the driving force behind tumorigenesis and possesses three basic requirements: (i) effective competitive proliferation of the variant clone when compared with its neighboring cells, (ii) acquisition of an indefinite capacity for self-renewal, and (iii) establishment of sufficiently high levels of genetic and epigenetic variability to permit the emergence of rare variants. However, several questions regarding the process of clonal evolution remain. Which cellular processes initiate carcinogenesis in the first place? To what extent are environmental carcinogens responsible for the initiation of clonal evolution? What are the roles of genotoxic and non-genotoxic carcinogens in carcinogenesis?
DescriptionCarnero, Amancio et al.
Publisher version (URL)http://doi.org/10.1093/carcin/bgv029
URIhttp://hdl.handle.net/10261/142998
DOIhttp://dx.doi.org/10.1093/carcin/bgv029
Identifierse-issn: 1460-2180
issn: 0143-3334
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