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ADAMTS proteoglycanases in the physiological and pathological central nervous system

AuthorsLemarchant, Sighild; Pruvost, Mathilde; Montaner, Joan; Emery, Evelyne; Vivien, Denis; Kanninen; Katja; Koistinaho, Jari
KeywordsA disintegrin and metalloproteinase with thrombospondin motifs
Spinal cord injury
Angiogenesis Neurorepair
Synaptic plasticity Inflammation
Chondroitin sulfate proteoglycan
Issue Date31-Oct-2013
PublisherBioMed Central
CitationJournal of Neuroinflammation 10: 133 (2013)
AbstractADAMTS-1, -4, -5 and -9 belong to ‘a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS)’ family and more precisely to the proteoglycanases subgroup based on their common ability to degrade chondroitin sulfate proteoglycans. They have been extensively investigated for their involvement in inflammation-induced osteoarthritis, and a growing body of evidence indicates that they may be of key importance in the physiological and pathological central nervous system (CNS). In this review, we discuss the deregulated expression of ADAMTS proteoglycanases during acute CNS injuries, such as stroke and spinal cord injury. Then, we provide new insights on ADAMTS proteoglycanases mediating synaptic plasticity, neurorepair, angiogenesis and inflammation mechanisms. Altogether, this review allows us to propose that ADAMTS proteoglycanases may be original therapeutic targets for CNS injuries.
Publisher version (URL)http://doi.org/10.1186/1742-2094-10-133
Identifiersissn: 1742-2094
Appears in Collections:(IBIS) Artículos
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