English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/142734
Share/Impact:
Statistics
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:

Title

Acinetobacter baumannii: Human infections, factors contributing to pathogenesis and animal models

AuthorsMcConnell, Michael J.; Actis, L. A.; Pachón, Jerónimo
KeywordsPathogenesis
Iron acquisition
Acinetobacter baumannii
Animal models
Virulence factors
Biofilm
Issue Date2013
PublisherOxford University Press
CitationFEMS Microbiology Reviews 37: 130-155 (2013)
AbstractAcinetobacter baumannii has emerged as a medically important pathogen because of the increasing number of infections produced by this organism over the preceding three decades and the global spread of strains with resistance to multiple antibiotic classes. In spite of its clinical relevance, until recently, there have been few studies addressing the factors that contribute to the pathogenesis of this organism. The availability of complete genome sequences, molecular tools for manipulating the bacterial genome, and animal models of infection have begun to facilitate the identification of factors that play a role in A. baumannii persistence and infection. This review summarizes the characteristics of A. baumannii that contribute to its pathogenesis, with a focus on motility, adherence, biofilm formation, and iron acquisition. In addition, the virulence factors that have been identified to date, which include the outer membrane protein OmpA, phospholipases, membrane polysaccharide components, penicillin-binding proteins, and outer membrane vesicles, are discussed. Animal models systems that have been developed during the last 15 years for the study of A. baumannii infection are overviewed, and the recent use of these models to identify factors involved in virulence and pathogenesis is highlighted. © 2012 Federation of European Microbiological Societies.
Publisher version (URL)http://doi.org/10.1111/j.1574-6976.2012.00344.x
URIhttp://hdl.handle.net/10261/142734
DOI10.1111/j.1574-6976.2012.00344.x
Identifiersissn: 0168-6445
e-issn: 1574-6976
Appears in Collections:(IBIS) Artículos
Files in This Item:
File Description SizeFormat 
accesoRestringido.pdf15,38 kBAdobe PDFThumbnail
View/Open
Show full item record
Review this work
 

Related articles:


WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.