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Differential expression of cro, the lysogenic cycle repressor determinant of bacteriophage A2, in Lactobacillus casei and Escherichia coli

AuthorsEscobedo, Susana; Rodríguez, Isabel; García Suárez, María Pilar ; Suárez Fernández, Juan Evaristo ; Carrasco, Begoña
KeywordsLactobacillus casei
Lysogenic cycle
Lytic cycle
Ribosome frameshift
Cro repressor
Bacteriophage A2
Issue Date21-Apr-2014
CitationVirus Research 183: 63-66 (2014)
AbstractExpression of bacteriophage A2-encoded cro in Escherichia coli gives rise to two co-linear polypeptides, Cro and Cro*, which were proposed to form a regulatory tandem to modulate the frequency with which the phage would choose between the lytic and the lysogenic cycles. In this communication, it is reported that Cro is the canonical product of the gene cro while Cro* results from a -1 ribosome frameshift during translation and is twelve amino acids shorter than Cro. However, frameshifting was not observed during phage development in Lactobacillus casei. Furthermore, wild type phages and cro-frameshifting negative mutants present the same phenotype, thus corroborating that only the canonical form of Cro is needed to produce a viable phage progeny. © 2014.
Publisher version (URL)https://doi.org/10.1016/j.virusres.2014.01.010
Identifiersissn: 1872-7492
Appears in Collections:(IPLA) Artículos
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