English   español  
Por favor, use este identificador para citar o enlazar a este item: http://hdl.handle.net/10261/142559
COMPARTIR / IMPACTO:
Estadísticas
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:
Título

Association of levels of antibodies from patients with inflammatory bowel disease with extracellular proteins of food and probiotic bacteria

AutorHevia, Arancha ; López, Patricia ; Suárez, Ana; Jacquot, Claudine; Urdaci, María C.; Margolles Barros, Abelardo ; Sánchez García, Borja
Fecha de publicación4-jun-2014
EditorHindawi Publishing Corporation
CitaciónBioMed Research International 2014: 351204 (2014)
ResumenInflammatory bowel disease (IBD) is an autoimmune disease characterized by a chronic inflammation of the gastrointestinal tract mucosa and is related to an abnormal immune response to commensal bacteria. Our aim of the present work has been to explore the levels of antibodies (IgG and IgA) raised against extracellular proteins produced by LAB and its association with IBD. We analyzed, by Western-blot and ELISA, the presence of serum antibodies (IgA and IgG) developed against extracellular protein fractions produced by different food bacteria from the genera Bifidobacterium and Lactobacillus. We used a sera collection consisting of healthy individuals (HC, n=50), Crohn's disease patients (CD, n=37), and ulcerative colitis patients (UC, n=15). Levels of IgA antibodies developed against a cell-wall hydrolase from Lactobacillus casei subsp. rhamnosus GG (CWH) were significantly higher in the IBD group (P<0.002; n=52). The specificity of our measurements was confirmed by measuring IgA antibodies developed against the CWH peptide 365-VNTSNQTAAVSAS- 377. IBD patients appeared to have different immune response to food bacteria. This paper sets the basis for developing systems for early detection of IBD, based on the association of high levels of antibodies developed against extracellular proteins from food and probiotic bacteria. © 2014 Arancha Hevia et al.
Versión del editorhttps://doi.org/10.1155/2014/351204
URIhttp://hdl.handle.net/10261/142559
DOI10.1155/2014/351204
Identificadoresissn: 2314-6141
Aparece en las colecciones: (IPLA) Artículos
Ficheros en este ítem:
Fichero Descripción Tamaño Formato  
Levels of Antibodies-Hevia.pdf1,62 MBAdobe PDFVista previa
Visualizar/Abrir
Mostrar el registro completo
 

Artículos relacionados:


NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.