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Título

Recent advances in the development of anti-infective prophylactic and/or therapeutic agents based on Toll-Like Receptor (TLRs)

AutorJunquera, Elena C.; Mateos-Hernández, Lourdes ; Fuente, José de la ; Lastra, José M. P. de la
Palabras claveToll-like receptors
Vaccine
Innate immunity
Immune therapy
Anti-infective agents
Agonist
Antagonist
Fecha de publicación2014
EditorBentham Science Publishers
CitaciónRecent Patents on Anti-Infective Drug Discovery 9(1): 14-24 (2014)
ResumenToll-like receptors (TLRs) are key players in innate immunity. They are able to sense different microorganisms ranging from protozoa to bacteria, fungi or viruses. Innate immune responses can directly influence adaptive immune responses. Therefore, TLRs are considered as relevant targets for therapeutic applications in immune diseases: such as autoimmune disorders, allergy, sepsis, and cancer. We here review the recent patents based on the modulation of the toll-like receptors to develop anti-infective (prophylactic and/or therapeutic) agents.
URIhttp://hdl.handle.net/10261/142525
DOI10.2174/1574891X09666140616164918
Identificadoresdoi: 10.2174/1574891X09666140616164918
issn: 1574-891X
e-issn: 2212-4071
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