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Recent advances in the development of anti-infective prophylactic and/or therapeutic agents based on Toll-Like Receptor (TLRs)

AuthorsJunquera, Elena C.; Mateos-Hernández, Lourdes ; Fuente, José de la ; Lastra, José M. P. de la
KeywordsToll-like receptors
Innate immunity
Immune therapy
Anti-infective agents
Issue Date2014
PublisherBentham Science Publishers
CitationRecent Patents on Anti-Infective Drug Discovery 9(1): 14-24 (2014)
AbstractToll-like receptors (TLRs) are key players in innate immunity. They are able to sense different microorganisms ranging from protozoa to bacteria, fungi or viruses. Innate immune responses can directly influence adaptive immune responses. Therefore, TLRs are considered as relevant targets for therapeutic applications in immune diseases: such as autoimmune disorders, allergy, sepsis, and cancer. We here review the recent patents based on the modulation of the toll-like receptors to develop anti-infective (prophylactic and/or therapeutic) agents.
Identifiersdoi: 10.2174/1574891X09666140616164918
issn: 1574-891X
e-issn: 2212-4071
Appears in Collections:(IPNA) Artículos
(IREC) Artículos
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