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Post-transcriptional regulation mediated by 3' mRNA regions in bacteria

AutorToledo-Arana, Alejandro
Fecha de publicacióndic-2015
CitaciónRegulating with RNA in Bacteria and Archaea Conference (2015)
ResumenThe central dogma of molecular biology states that messenger RNAs (mRNAs) are intermediary molecules required for the flow of genetic information from genomes to protein synthesis. However, mRNAs are now recognized to be central players with the capacity to “decide” when their own proteins (and others) will be translated. At both sides of the protein-coding region, mRNA molecules contain untranslated regions (UTRs) that encode additional information that is essential to modulate the timing and the quantity of the protein to be translated. For example, eukaryotic 3’-UTRs contain sequences and/or structures necessary to recruit essential proteins to modulate mRNA translation. Moreover, many eukaryotic 3’-UTRs carry specific sequences such as AU-rich and GU-rich elements (ARE and GRE motifs respectively), which are bound by specific RNA-binding proteins to increase mRNA decay and consequently inhibit protein translation. In addition, eukaryotic 3’-UTRs also carry target sequences that are recognized by microRNAs (miRNAs), which guide RNA-induced silencing complexes (RISCs) to down-regulate specific mRNAs. Recently, our group and others have shown that bacterial 3’-UTRs also contain regulatory elements that control mRNA translation and decay. In general, regulatory mechanisms mediated by bacterial 3’ mRNA regions can be separated into three main groups based on their action modes. The first one corresponds to 3’-UTRs that contain regulatory elements that modulate the expression of the protein encoded in the same mRNA. The second one corresponds to 3’ mRNA regions that overlap genes encoded at the opposite DNA strand, generating double-stranded RNA region s, which are substrates for the endoribonuclease III (RNase III). And, finally, the third group includes 3’-UTRs that generate small non-coding RNAs that will act over other RNA targets encoded in trans. Genome-wide transcriptomic analysis are revealing that these mechanisms are much more extended in prokaryotes than previously expected. In this talk, examples of post-transcriptional regulatory mechanisms mediated by 3’ mRNA regions that are associated to important biological processes will be discussed.
DescripciónTrabajo presentado en la Regulating with RNA in Bacteria and Archaea Conference, celebrada en Cancún del 5 al 8 de diciembre de 2015.
URIhttp://hdl.handle.net/10261/142375
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