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dc.contributor.authorCabezas-Cruz, Alejandro-
dc.contributor.authorMateos-Hernández, Lourdes-
dc.contributor.authorPérez-Cruz, Magdiel-
dc.contributor.authorValdés, James J.-
dc.contributor.authorFernández de Mera, Isabel G.-
dc.contributor.authorVillar, Margarita-
dc.contributor.authorFuente, José de la-
dc.date.accessioned2017-01-09T08:32:51Z-
dc.date.available2017-01-09T08:32:51Z-
dc.date.issued2015-
dc.identifierdoi: 10.1016/j.pt.2015.06.016-
dc.identifiere-issn: 1471-5007-
dc.identifierissn: 1471-4922-
dc.identifier.citationTrends in Parasitology 31(10): 470-476 (2015)-
dc.identifier.urihttp://hdl.handle.net/10261/142249-
dc.description.abstractVector-borne diseases (VBD) challenge our understanding of emerging diseases. Recently, arthropod vectors have been involved in emerging anaphylactic diseases. In particular, the immunoglobulin E (IgE) antibody response to the carbohydrate Galα1-3Galβ1-(3)4GlcNAc-R (α-gal) following a tick bite was associated with allergies to red meat, cetuximab, and gelatin. By contrast, an anti-α-gal IgM antibody response was shown to protect against mosquito-borne malaria. Herein, we highlight the interplay between the gut microbiota, vectors, transmitted pathogens, and the regulation of the immune response as a model to understand the protective or allergic effect of α-gal. Establishing the source of α-gal in arthropod vectors and the immune response to vector bites and transmitted pathogens will be essential for diagnosing, treating, and ultimately preventing these emerging anaphylactic and other vector-borne diseases.-
dc.description.sponsorshipPart of this research was supported by EU FP7 ANTIGONE project number 278976. J.J.V. was sponsored by project CZ.1.07/2.3.00/30.0032, co-financed by the European Social Fund and the state budget of the Czech Republic. A.C.C. was supported by a grant from the Ministère de l’Education Supérieure et de la Recherche of France.-
dc.publisherElsevier-
dc.relationinfo:eu-repo/grantAgreement/EC/FP7/278976-
dc.rightsclosedAccess-
dc.subjectα-gal-
dc.subjectVector-borne diseases-
dc.subjectTick-
dc.subjectMalaria-
dc.subjectVaccine-
dc.titleRegulation of the immune response to α-gal and vector-borne diseases-
dc.typeartículo-
dc.identifier.doi10.1016/j.pt.2015.06.016-
dc.date.updated2017-01-09T08:32:51Z-
dc.description.versionPeer Reviewed-
dc.language.rfc3066eng-
dc.contributor.funderEuropean Commission-
dc.contributor.funderCzech Science Foundation-
dc.contributor.funderMinistère de l’Enseignement supérieur et de la Recherche (France)-
dc.relation.csic-
dc.identifier.funderhttp://dx.doi.org/10.13039/501100000780es_ES
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