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Title

Regulation of the immune response to α-gal and vector-borne diseases

AuthorsCabezas-Cruz, Alejandro; Mateos-Hernández, Lourdes ; Pérez-Cruz, Magdiel; Valdés, James J.; Fernández de Mera, Isabel G.; Villar, Margarita ; Fuente, José de la
Keywordsα-gal
Vector-borne diseases
Tick
Malaria
Vaccine
Issue Date2015
PublisherElsevier
CitationTrends in Parasitology 31(10): 470-476 (2015)
AbstractVector-borne diseases (VBD) challenge our understanding of emerging diseases. Recently, arthropod vectors have been involved in emerging anaphylactic diseases. In particular, the immunoglobulin E (IgE) antibody response to the carbohydrate Galα1-3Galβ1-(3)4GlcNAc-R (α-gal) following a tick bite was associated with allergies to red meat, cetuximab, and gelatin. By contrast, an anti-α-gal IgM antibody response was shown to protect against mosquito-borne malaria. Herein, we highlight the interplay between the gut microbiota, vectors, transmitted pathogens, and the regulation of the immune response as a model to understand the protective or allergic effect of α-gal. Establishing the source of α-gal in arthropod vectors and the immune response to vector bites and transmitted pathogens will be essential for diagnosing, treating, and ultimately preventing these emerging anaphylactic and other vector-borne diseases.
URIhttp://hdl.handle.net/10261/142249
DOI10.1016/j.pt.2015.06.016
Identifiersdoi: 10.1016/j.pt.2015.06.016
e-issn: 1471-5007
issn: 1471-4922
Appears in Collections:(IREC) Artículos
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