English   español  
Por favor, use este identificador para citar o enlazar a este item: http://hdl.handle.net/10261/142145
COMPARTIR / IMPACTO:
Estadísticas
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:
Título

Perspectives on Intra- and Intercellular Trafficking of Hedgehog for Tissue Patterning

AutorSimon, Eléanor ; Aguirre-Tamaral, Adrián; Aguilar, Gustavo; Guerrero Vega, Isabel
Fecha de publicación2-dic-2016
EditorMultidisciplinary Digital Publishing Institute
CitaciónJournal of Developmental Biology 4(4): 34 (2016)
ResumenIntercellular communication is a fundamental process for correct tissue development. The mechanism of this process involves, among other things, the production and secretion of signaling molecules by specialized cell types and the capability of these signals to reach the target cells in order to trigger specific responses. Hedgehog (Hh) is one of the best-studied signaling pathways because of its importance during morphogenesis in many organisms. The Hh protein acts as a morphogen, activating its targets at a distance in a concentration-dependent manner. Post-translational modifications of Hh lead to a molecule covalently bond to two lipid moieties. These lipid modifications confer Hh high affinity to lipidic membranes, and intense studies have been carried out to explain its release into the extracellular matrix. This work reviews Hh molecule maturation, the intracellular recycling needed for its secretion and the proposed carriers to explain Hh transportation to the receiving cells. Special focus is placed on the role of specialized filopodia, also named cytonemes, in morphogen transport and gradient formation.
URIhttp://hdl.handle.net/10261/142145
DOIhttp://dx.doi.org/10.3390/jdb4040034
Identificadoresdoi: 10.3390/jdb4040034
Aparece en las colecciones: (CBM) Artículos
Ficheros en este ítem:
Fichero Descripción Tamaño Formato  
jdb-04-00034.pdf1,36 MBAdobe PDFVista previa
Visualizar/Abrir
Mostrar el registro completo
 


NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.