Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/142126
Share/Export:
logo share SHARE logo core CORE BASE
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE
Title

Controlling properties and cytotoxicity of chitosan nanocapsules by chemical grafting

AuthorsMatteis, Laura de; Alleva, María; Serrano-Sevilla, Inés; García-Embid, Sonia; Stepien, Grazyna; Ruíz del Árbol, María; Fuente, Jesús M. de la
Issue Date30-Sep-2016
PublisherMultidisciplinary Digital Publishing Institute
CitationMarine Drugs 14(10): 175 (2016)
AbstractThe tunability of the properties of chitosan-based carriers opens new ways for the application of drugs with low water-stability or high adverse effects. In this work, the combination of a nanoemulsion with a chitosan hydrogel coating and the following poly (ethylene glycol) (PEG) grafting is proven to be a promising strategy to obtain a flexible and versatile nanocarrier with an improved stability. Thanks to chitosan amino groups, a new easy and reproducible method to obtain nanocapsule grafting with PEG has been developed in this work, allowing a very good control and tunability of the properties of nanocapsule surface. Two different PEG densities of coverage are studied and the nanocapsule systems obtained are characterized at all steps of the optimization in terms of diameter, Z potential and surface charge (amino group analysis). Results obtained are compatible with a conformation of PEG molecules laying adsorbed on nanoparticle surface after covalent linking through their amino terminal moiety. An improvement in nanocapsule stability in physiological medium is observed with the highest PEG coverage density obtained. Cytotoxicity tests also demonstrate that grafting with PEG is an effective strategy to modulate the cytotoxicity of developed nanocapsules. Such results indicate the suitability of chitosan as protective coating for future studies oriented toward drug delivery.
Publisher version (URL)http://dx.doi.org/10.3390/md14100175
URIhttp://hdl.handle.net/10261/142126
DOI10.3390/md14100175
Appears in Collections:(ICMA) Artículos




Files in This Item:
File Description SizeFormat
marinedrugs-14-00175.pdf3,03 MBAdobe PDFThumbnail
View/Open
Show full item record
Review this work

PubMed Central
Citations

4
checked on May 25, 2022

SCOPUSTM   
Citations

21
checked on May 20, 2022

WEB OF SCIENCETM
Citations

20
checked on May 25, 2022

Page view(s)

202
checked on May 26, 2022

Download(s)

195
checked on May 26, 2022

Google ScholarTM

Check

Altmetric

Dimensions


Related articles:


WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.