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The p22 RNA Silencing Suppressor of the Crinivirus Tomato chlorosis virus is Dispensable for Local Viral Replication but Important for Counteracting an Antiviral RDR6-Mediated Response during Systemic Infection

AutorLandeo-Ríos, Yazmín; Navas-Castillo, Jesús; Moriones, Enrique; Cañizares, M. Carmen
Fecha de publicación28-jun-2016
EditorMultidisciplinary Digital Publishing Institute
CitaciónViruses 8(7): 182 (2016)
ResumenAmong the components of the RNA silencing pathway in plants, RNA-dependent RNA polymerases (RDRs) play fundamental roles in antiviral defence. Here, we demonstrate that the <i>Nicotiana benthamiana</i> RDR6 is involved in defence against the bipartite crinivirus (genus <i>Crinivirus</i>, family <i>Closteroviridae</i>) <i>Tomato chlorosis virus</i> (ToCV). Additionally, by producing a p22-deficient ToCV infectious mutant clone (ToCVΔp22), we studied the role of this viral suppressor of RNA silencing in viral infection in both wild-type and RDR6-silenced <i>N. benthamiana</i> (NbRDR6i) plants. We demonstrate that p22 is dispensable for the replication of ToCV, where RDR6 appears not to have any effect. Furthermore, the finding that ToCV∆p22 systemic accumulation was impaired in wild-type <i>N. benthamiana</i> but not in NbRDR6i plants suggests a role for p22 in counteracting an RDR6-mediated antiviral response of the plant during systemic infection.
URIhttp://hdl.handle.net/10261/142073
DOIhttp://dx.doi.org/10.3390/v8070182
Identificadoresdoi: 10.3390/v8070182
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