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Título

Goats challenged with different members of the Mycobacterium tuberculosis complex display different clinical pictures

AutorBezos, Javier; Casal, Carmen; Díez-Delgado, Iratxe CSIC ORCID; Romero, Beatriz; Álvarez, Julio CSIC ORCID; Sevilla, Iker A.; Juan, Lucía de; Domínguez, Lucas CSIC; Gortázar, Christian CSIC ORCID
Palabras claveAnimal tuberculosis
Strain genotype
Shedding
Lesion score
Domestic goat
Fecha de publicación2015
EditorElsevier
CitaciónVeterinary Immunology and Immunopathology 167(3-4): 185-189 (2015)
ResumenTuberculosis (TB) in goats (. Capra hircus) is due to infection with members of the Mycobacterium tuberculosis complex (MTC), mainly Mycobacterium bovis and Mycobacterium caprae. We report a comparative experimental infection of goats with M. bovis, M. caprae and M. tuberculosis strains. We hypothesized that goats experimentally infected with different members of the MTC would display different clinical pictures. Three groups of goats were challenged with either M. bovis SB0134 (group 1, n=. 5), M. caprae SB0157 (group 2, n=. 5) and M. tuberculosis SIT58 (group 3, n= 4). The highest mean total lesion score was observed in M. bovis challenged goats (mean 15.2, range 9-19), followed by those challenged with M. caprae (10.8, 2-23). The lowest score was recorded in goats challenged with M. tuberculosis (3, 1-6). Culture results coincided with the lesion scores in yielding more positive pools (7/15) in M. bovis challenged goats. By contrast, only three pools were positive from goats challenged M. tuberculosis (3/12) and with M. caprae (3/15), respectively. Differences in the performance of the intradermal and gamma-interferon (IFN-γ) tests depending of the group were observed since all goats from group 1 were diagnosed using intradermal test and these goats reacted earlier to the IFN-γ assay in comparison to the other groups. This study confirmed that goats experimentally infected with different members of the MTC display different clinical pictures and this fact may have implications for MTC maintenance and bacterial shedding.
URIhttp://hdl.handle.net/10261/142001
DOI10.1016/j.vetimm.2015.07.009
Identificadoresdoi: 10.1016/j.vetimm.2015.07.009
e-issn: 1873-2534
issn: 0165-2427
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