English   español  
Por favor, use este identificador para citar o enlazar a este item: http://hdl.handle.net/10261/142001
COMPARTIR / IMPACTO:
Estadísticas
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:
Título

Goats challenged with different members of the Mycobacterium tuberculosis complex display different clinical pictures

AutorBezos, Javier; Casal, Carmen; Díez-Delgado, Iratxe ; Romero, Beatriz; Álvarez, Julio ; Sevilla, Iker A.; Juan, Lucía de; Domínguez, Lucas; Gortázar, Christian
Palabras claveAnimal tuberculosis
Strain genotype
Shedding
Lesion score
Domestic goat
Fecha de publicación2015
EditorElsevier
CitaciónVeterinary Immunology and Immunopathology 167(3-4): 185-189 (2015)
ResumenTuberculosis (TB) in goats (. Capra hircus) is due to infection with members of the Mycobacterium tuberculosis complex (MTC), mainly Mycobacterium bovis and Mycobacterium caprae. We report a comparative experimental infection of goats with M. bovis, M. caprae and M. tuberculosis strains. We hypothesized that goats experimentally infected with different members of the MTC would display different clinical pictures. Three groups of goats were challenged with either M. bovis SB0134 (group 1, n=. 5), M. caprae SB0157 (group 2, n=. 5) and M. tuberculosis SIT58 (group 3, n= 4). The highest mean total lesion score was observed in M. bovis challenged goats (mean 15.2, range 9-19), followed by those challenged with M. caprae (10.8, 2-23). The lowest score was recorded in goats challenged with M. tuberculosis (3, 1-6). Culture results coincided with the lesion scores in yielding more positive pools (7/15) in M. bovis challenged goats. By contrast, only three pools were positive from goats challenged M. tuberculosis (3/12) and with M. caprae (3/15), respectively. Differences in the performance of the intradermal and gamma-interferon (IFN-γ) tests depending of the group were observed since all goats from group 1 were diagnosed using intradermal test and these goats reacted earlier to the IFN-γ assay in comparison to the other groups. This study confirmed that goats experimentally infected with different members of the MTC display different clinical pictures and this fact may have implications for MTC maintenance and bacterial shedding.
URIhttp://hdl.handle.net/10261/142001
DOI10.1016/j.vetimm.2015.07.009
Identificadoresdoi: 10.1016/j.vetimm.2015.07.009
e-issn: 1873-2534
issn: 0165-2427
Aparece en las colecciones: (IREC) Artículos
Ficheros en este ítem:
Fichero Descripción Tamaño Formato  
accesoRestringido.pdf15,38 kBAdobe PDFVista previa
Visualizar/Abrir
Mostrar el registro completo
 

Artículos relacionados:


NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.