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H2-fueled ATP synthesis on an electrode: Mimicking cellular respiration

AuthorsGutiérrez-Sanz, Óscar ; Natale, Paolo; Márquez, Ileana F. ; Marques, Marta C.; Zacarias, Sonia; Pita, Marcos ; Pereira, Inês A. C.; López-Montero, Iván; López de Lacey, Antonio ; Vélez, Marisela
KeywordsMembrane proteins
Proton transport
Issue Date2016
CitationAngewandte Chemie 128(1): 6216-6220 (2016)
AbstractATP, the molecule used by living organisms to supply energy to many different metabolic processes, is synthesized mostly by the ATPase synthase using a proton or sodium gradient generated across a lipid membrane. We present evidence that a modified electrode surface integrating a NiFeSe hydrogenase and a FF-ATPase in a lipid membrane can couple the electrochemical oxidation of H to the synthesis of ATP. This electrode-assisted conversion of H gas into ATP could serve to generate this biochemical fuel locally when required in biomedical devices or enzymatic synthesis of valuable products. ATP synthesis fueled by H: A gold electrode modified with an oriented membrane-bound NiFeSe hydrogenase, a lipid membrane, and an integrated FF-ATPase generates a local proton gradient by electroenzymatic H oxidation, which is then used to synthesize ATP. This electrode-assisted conversion of H into ATP could locally generate biochemical fuel in medical devices or enzymatic synthesis.
Publisher version (URL)http://doi.org/10.1002/ange.201600752
Identifiersdoi: 10.1002/ange.201600752
issn: 0044-8249
e-issn: 1521-3757
Appears in Collections:(ICP) Artículos
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