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Título

H2-fueled ATP synthesis on an electrode: Mimicking cellular respiration

AutorGutiérrez-Sanz, Óscar CSIC ORCID; Natale, Paolo; Márquez, Ileana F. CSIC; Marques, Marta C.; Zacarias, Sonia; Pita, Marcos CSIC ORCID ; Pereira, Inês A. C.; López-Montero, Iván; López de Lacey, Antonio CSIC ORCID ; Vélez, Marisela CSIC ORCID
Palabras claveMembrane proteins
Immobilization
Biophysics
Bioelectrochemistry
Proton transport
Fecha de publicación2016
EditorWiley-VCH
CitaciónAngewandte Chemie 128(1): 6216-6220 (2016)
ResumenATP, the molecule used by living organisms to supply energy to many different metabolic processes, is synthesized mostly by the ATPase synthase using a proton or sodium gradient generated across a lipid membrane. We present evidence that a modified electrode surface integrating a NiFeSe hydrogenase and a FF-ATPase in a lipid membrane can couple the electrochemical oxidation of H to the synthesis of ATP. This electrode-assisted conversion of H gas into ATP could serve to generate this biochemical fuel locally when required in biomedical devices or enzymatic synthesis of valuable products. ATP synthesis fueled by H: A gold electrode modified with an oriented membrane-bound NiFeSe hydrogenase, a lipid membrane, and an integrated FF-ATPase generates a local proton gradient by electroenzymatic H oxidation, which is then used to synthesize ATP. This electrode-assisted conversion of H into ATP could locally generate biochemical fuel in medical devices or enzymatic synthesis.
Versión del editorhttp://doi.org/10.1002/ange.201600752
URIhttp://hdl.handle.net/10261/141934
DOI10.1002/ange.201600752
Identificadoresdoi: 10.1002/ange.201600752
issn: 0044-8249
e-issn: 1521-3757
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