English   español  
Por favor, use este identificador para citar o enlazar a este item: http://hdl.handle.net/10261/141934
Compartir / Impacto:
Estadísticas
Add this article to your Mendeley library MendeleyBASE
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Título

H2-fueled ATP synthesis on an electrode: Mimicking cellular respiration

AutorGutiérrez-Sanz, Óscar; Natale, Paolo; Márquez, Ileana; Marques, Marta C.; Zacarías, Sonia; Pita, Marcos ; Pereira, Inés A. C.; López-Montero, Iván; De Lacey, Antonio L.; Vélez, Marisela
Palabras claveMembrane proteins
Immobilization
Biophysics
Bioelectrochemistry
Proton transport
Fecha de publicación2016
EditorWiley-VCH
CitaciónAngewandte Chemie 128 (1): 6216-6220 (2016)
Resumen[EN] ATP, the molecule used by living organisms to supply energy to many different metabolic processes, is synthesized mostly by the ATPase synthase using a proton or sodium gradient generated across a lipid membrane. We present evidence that a modified electrode surface integrating a NiFeSe hydrogenase and a FF-ATPase in a lipid membrane can couple the electrochemical oxidation of H to the synthesis of ATP. This electrode-assisted conversion of H gas into ATP could serve to generate this biochemical fuel locally when required in biomedical devices or enzymatic synthesis of valuable products. ATP synthesis fueled by H: A gold electrode modified with an oriented membrane-bound NiFeSe hydrogenase, a lipid membrane, and an integrated FF-ATPase generates a local proton gradient by electroenzymatic H oxidation, which is then used to synthesize ATP. This electrode-assisted conversion of H into ATP could locally generate biochemical fuel in medical devices or enzymatic synthesis.
URIhttp://hdl.handle.net/10261/141934
DOI10.1002/ange.201600752
Identificadoresdoi: 10.1002/ange.201600752
issn: 0044-8249
e-issn: 1521-3757
Aparece en las colecciones: (ICP) Artículos
Ficheros en este ítem:
Fichero Descripción Tamaño Formato  
H2-Fueled_ATP_Synthesis_on_an_Electrode_Mimicking_Cellular_Respiration.pdf1,71 MBAdobe PDFVista previa
Visualizar/Abrir
Mostrar el registro completo
 


NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.