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Synthesis of axially chiral heterobiaryl alkynes via dynamic kinetic asymmetric alkynylation

AuthorsHornillos, Valentín ; Ros, Abel ; Ramírez-López, Pedro; Iglesias-Sigüenza, Javier; Fernández, Rosario; Lassaletta, José M.
Issue Date2016
PublisherRoyal Society of Chemistry
CitationChemical Communications 52(98) 14121-14124 (2016)
AbstractThe dynamic kinetic Pd0-catalyzed alkynylation of racemic heterobiaryl sulfonates was used for the asymmetric synthesis of axially chiral heterobiaryl alkynes with a broad scope. The use of Pd(OAc)2/(S)-QUINAP as the precatalyst provides products in excellent yields and enantioselectivities under mild conditions (DMSO, 40 °C). Semireduction, 1,3-dipolar cycladdition or N-oxidation served to illustrate the synthetic potential of the methodology.
Publisher version (URL)http://dx.doi.org/ 10.1039/C6CC08997F
Appears in Collections:(IIQ) Artículos
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