English   español  
Por favor, use este identificador para citar o enlazar a este item: http://hdl.handle.net/10261/1419
Compartir / Impacto:
Estadísticas
Add this article to your Mendeley library MendeleyBASE
 |  Pub MebCentral Ver citas en PubMed Central  |  Ver citas en Google académico
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar otros formatos: Exportar EndNote (RIS)Exportar EndNote (RIS)Exportar EndNote (RIS)
Título : Infection with Anaplasma phagocytophilum in a seronegative patient in Sicily, Italy: Case Report
Autor : Fuente, José de la; Torina, Alessandra; Naranjo, María Victoria; Caracappa, Santo; Di Marco, Vincenzo
Palabras clave : Anaplasma phagocytophilum
Human granulocytic anaplasmosis
16S rDNA
Fecha de publicación : 3-oct-2005
Editor: BioMed Central
Citación : Annals of Clinical Microbiology and Antimicrobials 2005, 4:15
Resumen: [Background] Anaplasma phagocytophilum causes human granulocytic anaplasmosis (HGA) in humans, which has been recognized as an emerging tick-borne disease in the United States and Europe. Although about 65 cases of HGA have been reported in Europe, some of them do not fulfill the criteria for confirmed HGA. Confirmation of HGA requires A. phagocytophilum isolation from blood, and/or identification of morulae in granulocytes and/or positive PCR results with subsequent sequencing of the amplicons to demonstrate specific rickettsial DNA. Seroconversion or at least fourfold increase in antibody titers to A. phagocytophilum has been used as criteria for confirmed HGA also.
[Case presentation] Infection with A. phagocytophilum was confirmed by PCR in a patient in Sicily, Italy, who had negative serology for A. phagocytophilum. A fragment of A. phagocytophilum 16S rDNA was amplified by two independent laboratories and sequenced from two separate patient's blood samples. The 16S rDNA sequence was identical in both samples and identical to the sequence of the A. phagocytophilum strain USG3 originally obtained from a dog.
[Conclusion] Infection with A. phagocytophilum was confirmed in a patient without a detectable antibody response against the pathogen. The results reported herein documented the first case of confirmed HGA in Sicily, Italy. These results suggested the possibility of human infections with A. phagocytophilum strains that result in clinical symptoms and laboratory findings confirmatory of HGA but without detectable antibodies against the pathogen.
Versión del editor: http://dx.doi.org/10.1186/1476-0711-4-15
URI : http://hdl.handle.net/10261/1419
DOI: 10.1186/1476-0711-4-15
ISSN: 1476-0711
Aparece en las colecciones: (IREC) Artículos
Ficheros en este ítem:
Fichero Descripción Tamaño Formato  
Infection+with+Anaplasma+phagocytophilum.pdf210,43 kBAdobe PDFVista previa
Visualizar/Abrir
Mostrar el registro completo
 

Artículos relacionados:


NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.