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Título

Role of non-coding RNAs in the transgenerational epigenetic transmission of the effects of reprotoxicants

AutorLarriba, E.; Del Mazo, Jesús
Palabras claveEndocrine disruptors
Epigenetics
lncRNAs
MicroRNAs;
Non-coding RNAs
piRNAs
Reproduction
Reprotoxicants
Reprotoxicology;
Transgenerational transmission
Fecha de publicación25-mar-2016
EditorMultidisciplinary Digital Publishing Institute
CitaciónInt J Mol Sci. 17(4):452 (2016 )
ResumenNon-coding RNAs (ncRNAs) are regulatory elements of gene expression and chromatin structure. Both long and small ncRNAs can also act as inductors and targets of epigenetic programs. Epigenetic patterns can be transmitted from one cell to the daughter cell, but, importantly, also through generations. Diversity of ncRNAs is emerging with new and surprising roles. Functional interactions among ncRNAs and between specific ncRNAs and structural elements of the chromatin are drawing a complex landscape. In this scenario, epigenetic changes induced by environmental stressors, including reprotoxicants, can explain some transgenerationally-transmitted phenotypes in non-Mendelian ways. In this review, we analyze mechanisms of action of reprotoxicants upon different types of ncRNAs and epigenetic modifications causing transgenerationally transmitted characters through germ cells but affecting germ cells and reproductive systems. A functional model of epigenetic mechanisms of transgenerational transmission ncRNAs-mediated is also proposed.
Descripción13 p.-1 fig.
Versión del editorhttp://dx.doi.org/10.3390/ijms17040452
URIhttp://hdl.handle.net/10261/141873
DOI10.3390/ijms17040452
ISSN1661-6596
E-ISSN1422-0067
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