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Title

Endocrine disrupters, microRNAs, and primordial germ cells: a dangerous cocktail

AuthorsBrieño-Enríquez, Miguel A.; Larriba, E.; Del Mazo, Jesús
KeywordsEndocrine disruptors
PGCs
miRNAs
Reproduction
Transgenerational
Issue Date15-Sep-2016
PublisherElsevier
CitationFertil Steril. 106(4):871-9 (2016)
AbstractEndocrine-disrupting chemicals (EDCs) are environmental pollutants that may change the homeostasis of the endocrine system, altering the differentiation of germ cells with consequences for reproduction. In mammals, germ cell differentiation begins with primordial germ cells (PGCs) during embryogenesis. Primordial germ cell development and gametogenesis are genetically regulated processes, in which the posttranscriptional gene regulation could be mediated by small noncoding RNAs (sncRNAs) such as microRNAs (miRNAs). Here, we review the deleterious effects of exposure during fetal life to EDCs mediated by deregulation of ncRNAs, and specifically miRNAs on PGC differentiation. Moreover, the environmental stress induced by exposure to some EDCs during the embryonic window of development could trigger reproductive dysfunctions transgenerationally transmitted by epigenetic mechanisms with the involvement of miRNAs expressed in germ line cells.
Description29 p.-2 fig.
Publisher version (URL)http://dx.doi.org/10.1016/j.fertnstert.2016.07.1100
URIhttp://hdl.handle.net/10261/141858
DOI10.1016/j.fertnstert.2016.07.1100
ISSN0015-0282
E-ISSN1556-5653
Appears in Collections:(CIB) Artículos
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