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Experimental North American West Nile virus infection in the red-legged partridge (Alectoris rufa)

AutorGamino, Virginia ; Escribano-Romero, Estela; Blázquez, Ana B.; Gutiérrez-Guzmán, Ana Valeria; Martín-Acebes, Miguel Ángel; Saiz, Juan Carlos; Höfle, Ursula
Palabras claveFlavivirus
Experimental infection
Encephalitis
Histopathology
West Nile virus
Immunohistochemistry
Pathogenesis
Red-legged partridge Alectoris rufa
Fecha de publicación2015
EditorSage Publications
CitaciónVeterinary Pathology 53(3): 585-593 (2015)
ResumenAfter the introduction of West Nile virus (WNV) into North America, bird mortalities associated with West Nile disease have dramatically increased in this continent and, to a lesser extent, in Europe. The different West Nile disease incidence in birds in these 2 continents demands an explanation, and experimental studies can provide important information. The authors inoculated thirteen 9-week-old red-legged partridges (Alectoris rufa) with 10 plaque-forming units of a WNV strain isolated in New York in 1999. The objective was to study the pathogenesis of the infection in a native Euro-Mediterranean bird species with a WNV strain known to be highly pathogenic for numerous native American bird species. Additionally, the authors evaluated the dynamics of inflammatory cell activation and recruitment into the brain. WNV was detected in tissues 3 days postinoculation (dpi), and the birds developed macroscopic and microscopic lesions. Two partridges succumbed to the disease. The most affected tissues were the heart, brain, and spinal cord. The main microscopic findings were the presence of mononuclear infiltrates in the heart and brain, gliosis, and degeneration and necrosis of cardiomyocytes and neurons. These lesions were aggravated in the birds that died or were euthanized 7 dpi or later. In the brain, there was an upregulation of microglial cells and astrocytes and an increase in the number of T cells, especially after 7 dpi. These results show that this WNV strain is of moderate virulence for the red-legged partridge and that WNV-infected red-legged partridges develop an immune cell response in the brain similar to that of mammals.
Versión del editorhttps://doi.org/10.1177/0300985815612554
URIhttp://hdl.handle.net/10261/141855
DOI10.1177/0300985815612554
Identificadoresdoi: 10.1177/0300985815612554
e-issn: 1544-2217
issn: 0300-9858
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