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Anaplasma marginale major surface protein 1a: a marker of strain diversity with implications for control of bovine anaplasmosis

AutorCabezas-Cruz, Alejandro; Fuente, José de la
Palabras claveGenetic diversity
Molecular diagnostics
A. marginale
Fecha de publicación2015
CitaciónTicks and Tick-borne Diseases 6(3): 205-210 (2015)
ResumenClassification of bacteria is challenging due to the lack of a theory-based framework. In addition, the adaptation of bacteria to ecological niches often results in selection of strains with diverse virulence, pathogenicity and transmission characteristics. Bacterial strain diversity presents challenges for taxonomic classification, which in turn impacts the ability to develop accurate diagnostics and effective vaccines. Over the past decade, the worldwide diversity of Anaplasma marginale, an economically important tick-borne pathogen of cattle, has become apparent. The extent of A. marginale strain diversity, formerly underappreciated, has contributed to the challenges of classification which, in turn, likely impacts the design and development of improved vaccines. Notably, the A. marginale surface protein 1a (MSP1a) is a model molecule for these studies because it serves as a marker for strain identity, is both an adhesin necessary for infection of cells and an immuno-reactive protein and is also an indicator of the evolution of strain diversity. Herein, we discuss a molecular taxonomic approach for classification of A. marginale strain diversity. Taxonomic analysis of this important molecule provides the opportunity to understand A. marginale strain diversity as it relates geographic and ecological factors and to the development of effective vaccines for control of bovine anaplasmosis worldwide.
Identificadoresdoi: 10.1016/j.ttbdis.2015.03.007
e-issn: 1877-9603
issn: 1877-959X
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