English   español  
Por favor, use este identificador para citar o enlazar a este item: http://hdl.handle.net/10261/141612
Título

Increased lytic efficiency of bovine macrophages trained with killed mycobacteria

AutorJuste, Ramón A.; Alonso-Hearn, Marta; Garrido, Joseba M.; Abendaño, Naiara; Sevilla, Iker A.; Gortázar, Christian ; Fuente, José de la ; Domínguez, Lucas
Fecha de publicación2016
EditorPublic Library of Science
CitaciónPLoS ONE 11(11): e0165607 (2016)
ResumenInnate immunity is evolutionarily conserved in multicellular organisms and was considered to lack memory until very recently. One of its more characteristic mechanisms is phagocytosis, the ability of cells to engulf, process and eventually destroy any injuring agent. We report the results of an ex vivo experiment in bovine macrophages in which improved clearance of Mycobacterium bovis (M. bovis) was induced by pre-exposure to a heat killed M. bovis preparation. The effects were independent of humoral and cellular adaptive immune responses and lasted up to six months. Specifically, our results demonstrate the existence of a training effect in the lytic phase of phagocytosis that can be activated by killed mycobacteria, thus suggesting a new mechanism of vaccine protection. These findings are compatible with the recently proposed concept of trained immunity, which was developed to explain the observation that innate immune responses provide unspecific protection against pathogens including other than those that originally triggered the immune response.
Versión del editorhttp://dx.doi.org/10.1371/journal.pone.0165607
URIhttp://hdl.handle.net/10261/141612
DOI10.1371/journal.pone.0165607
Identificadoresdoi: 10.1371/journal.pone.0165607
e-issn: 1932-6203
Aparece en las colecciones: (IREC) Artículos
Ficheros en este ítem:
Fichero Descripción Tamaño Formato  
KilledMycobacteria.PDF1,69 MBAdobe PDFVista previa
Visualizar/Abrir
Mostrar el registro completo
 

Artículos relacionados:


NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.