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Título

Effects of sodium butyrate treatment on histone modifications and the expression of genes related to epigenetic regulatory mechanisms and immune response in European sea bass (Dicentrarchus labrax) fed with a diet partially substituted with vegetable oils

AutorTerova, G.; Rimoldi, S.; Díaz, Noelia ; Piferrer, Francesc ; Saroglia, M.
Fecha de publicación7-oct-2015
CitaciónEpigenetics and Periconception Environment : Proceedings of the EPICONCEPT Conference 2015: 75 (2015)
ResumenBacteria that inhabit the epithelium of the animal’s digestive tract, play a critical role in the establishment and maintenance of their hosts’ health. The intestinal microbiota is involved in the anaerobic fermentation of dietary otherwise indigestible carbohydrates producing short chain fatty acids (SCFAs). Butyrate is a SCFA extensively used in animal nutrition since it promotes increases in body weight and other multiple beneficial effects on the intestinal tract. Although such effects have been demonstrated in several species, very few studies have assessed them in fish. In the present work, growth parameters and changes in the expression of several inflammation-related genes have been quantified in the intestine and liver of European sea bass fed on a butyrate-supplemented diet. Results showed a significant increase in the weight of fish receiving butyrate, whereas gene expression provided some clues on the suggested effects of this feed additive. Indeed, four genes (il1β, il8, irf1 and tnfα) showed significant differences in the expression between the two tissues but only interleukin 10 ( il10) showed differences due to the butyrate treatment. Moreover, since butyrate acts as a potent histone deacetylase inhibitor, we also determined the effect of butyrate treatment on the expression of a suite of genes related to epigenetic modification that, in addition, are known to be influenced by the rearing environment (temperature) in the European sea bass. These genes modified their expression and included: 1) dicer 1, which encodes an active small RNA component that represses gene expression, 2) ehmt2, which demethylates Lys9 in histone3 in euchromatin, creating a tag for epigenetic transcription repression, 3) pcfg2, which acts via chromatin remodeling and histone modification, 4) hdac11, which modifies core histone octamers and influence the packing of chromatin in dense structures or controls various histone methyltransferase complexes (jarid2a)
DescripciónEpigenetics and Periconception Environment : Proceedings of the EPICONCEPT Conference 2015, 6-7 October 2015, Hersonissos, Crete, Greece.-- 1 page
Versión del editorhttp://cost-epiconcept.eu/conference_2015.html
URIhttp://hdl.handle.net/10261/141528
Identificadoresisbn: 978-960-6806-16-2
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