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Título

Genomics of the genus Bifidobacterium reveals species-specific adaptation to the glycan-rich gut environment

AutorMilani, Christian; Margolles Barros, Abelardo ; Ventura, Marco
Fecha de publicación31-ago-2014
Citación11th Symposium on Lactic Acid Bacteria (2014)
ResumenBifidobacteria have been identified in the gut environment of a diverse set of animals, including those of mammals and insects. However, the genetic traits facilitating their adaptation to this highly competitive and variable ecological niche are still poorly characterized. Here, the genomic decoding of 47 representative (sub)species across the Bifidobacterium genus revealed a wide variety of genes predicted to be required for the breakdown and internalization of a range of carbohydrates. Such glycan-degrading abilities are expected to be a reflection of the carbon sources present in the ecological niche of bifidobacteria. Furthermore, transcriptome profiling of bifidobacterial genomes supported the involvement of various chromosomal loci in glycan metabolism. The widespread occurrence of bifidobacterial saccharolytic features was confirmed by interrogating metagenomic datasets, thereby supporting the notion that metabolic accessibility to dietary and/or host derived glycans is a potent evolutionary force that has shaped bifidobacterial genomes. This study also underscores the idea of saccharidic resource sharing among bifidobacteria through species-specific metabolic specialization and cross feeding.
DescripciónTrabajo presentado en el 11th Symposium on Lactic Acid Bacteria, celebrado en Egmond aan Zee, Países Bajos, del 31 de agosto al 4 de septiembre de 2014
URIhttp://hdl.handle.net/10261/141471
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