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Evaluation of Surface Microtopography Engineered by Direct Laser Interference for Bacterial Anti-Biofouling

AuthorsValle Turrillas, Jaione ; Burgui, Saioa; Langheinrich, Denise; Gil Puig, Carmen; Solano Goñi, Cristina ; Toledo-Arana, Alejandro ; Helbig, Ralf; Lasagni, Andrés; Lasa, Íñigo
Issue DateAug-2015
PublisherJohn Wiley & Sons
CitationMacromolecular Bioscience 15(8): 1060-1069 (2015)
Abstract© 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. Modification of the biomaterial surface topography is a promising strategy to prevent bacterial adhesion and biofilm formation. In this study, we use direct laser interference patterning (DLIP) to modify polystyrene surface topography at sub-micrometer scale. The results revealed that three-dimensional micrometer structures have a profound impact on bacterial adhesion. Thus, line- and pillar-like patterns enhanced S. aureus adhesion, whereas complex lamella microtopography reduced S. aureus adhesion in static and continuous flow culture conditions. Interestingly, lamella-like textured surfaces retained the capacity to inhibit S. aureus adhesion both when the surface is coated with human serum proteins and when the material is implanted subcutaneously in a foreign-body associated infection model.
Publisher version (URL)http://doi.org/10.1002/mabi.201500107
Identifiersissn: 1616-5195
Appears in Collections:(IDAB) Artículos
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