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The mineralocorticoid receptor plays a transient role in mouse skin development

AuthorsBoix, Julia; Carceller, Elena; Sevilla, Lisa M. ; Marcos-Garcés, V.; Pérez, Paloma
Glucocorticoid receptor
Mineralocorticoid receptor
Issue Date2016
CitationExperimental Dermatology 25: 69-71 (2016)
AbstractGlucocorticoid (GC) hormones can bind two structurally and functionally related steroid receptors: the GC Receptor (GR or Nr3c1) and the mineralocorticoid receptor (MR or Nr3c2), which recognize the same DNA response elements and act as ligand-dependent transcription factors. While the crucial role of GR for skin homeostasis has been widely characterized, the exact role of MR in this tissue deserves further study. We assessed NR3C2 expression in developing and adult WT mouse skin and found a transient peak at embryonic day (E)16.5, which along with low levels of HSD11B2, the enzyme inactivating GCs, supports a role for GC-MR complexes in epidermal maturation. Consistent with this observation, MR-/- embryonic skin showed alterations in early epidermal differentiation that resolved postnatally. The lack of a more severe skin phenotype of MR-/- mice suggests functional compensation by GR in this tissue in the perinatal period.
Description3 páginas, 2 figuras. Contiene material suplemenario
Identifiersdoi: 10.1111/exd.12822
e-issn: 1600-0625
issn: 0906-6705
Appears in Collections:(IBV) Artículos
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