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Title

Amyloid structures as biofilm matrix scaffolds

AuthorsTaglialegna, Agustina ; Lasa, Íñigo ; Valle Turrillas, Jaione
Issue DateOct-2016
PublisherAmerican Society for Microbiology
CitationJournal of Bacteriology 198(19): 2579-2588 (2016)
AbstractRecent insights into bacterial biofilm matrix structures have induced a paradigm shift toward the recognition of amyloid fibers as common building block structures that confer stability to the exopolysaccharide matrix. Here we describe the functional amyloid systems related to biofilm matrix formation in both Gram-negative and Gram-positive bacteria and recent knowledge regarding the interaction of amyloids with other biofilm matrix components such as extracellular DNA (eDNA) and the host immune system. In addition, we summarize the efforts to identify compounds that target amyloid fibers for therapeutic purposes and recent developments that take advantage of the amyloid structure to engineer amyloid fibers of bacterial biofilm matrices for biotechnological applications.
Publisher version (URL)http://doi.org/10.1128/JB.00122-16
URIhttp://hdl.handle.net/10261/141182
DOI10.1128/JB.00122-16
Identifierse-issn: 1098-5530
issn: 0021-9193
Appears in Collections:(IDAB) Artículos
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