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Title

DNA-controlled assembly of protein-modified gold nanocrystals

AuthorsCobbe, Stephen; Connolly, Stephen A.; Ryan, Declan E.; Nagle, Lorraine C.; Eritja Casadellà, Ramón; Fitzmaurice, Donald J.
KeywordsDNA
Gold
Gold nanocrystals
Nanostructured materials
Issue Date16-Jan-2003
PublisherAmerican Chemical Society
CitationJournal of Physical Chemistry B - Condensed Phase 107 (2): 470-477 (2003)
AbstractThe controlled assembly in solution of gold nanocrystals modified by attachment of complementary protein-DNA conjugates is described. The size of the aggregates formed can be controlled by the addition of single-stranded DNA, which quickly terminates the assembly process. The rate of formation of the aggregates can also be controlled by varying the salt concentration. Consequently, two distinct regimes of aggregation kinetics are observed. At low salt concentrations, aggregation is shown to be dependent on the rate of duplex formation between the modified gold nanocrystals, i.e., reaction-limited. At higher salt concentrations, aggregation is shown to be dependent only on the rate of diffusion of the nanocrystals, i.e., diffusion-limited. The results presented provide important insights into the rates of formation of nanocrystal assemblies. Moreover, the approach adopted is modular, requiring only the relevant biotin linker chemistry to be developed for a given nanoparticle, while also precluding unfavorable interactions between the DNA and the streptavidin-coated nanoparticle. The ability to control the rate of formation and size of nanocrystal aggregates assembled is important new knowledge. Application of this knowledge will inform future studies of nanocrystal assembly in solution involving different types of nanocrystals, which is of increasing technological significance.
Publisher version (URL)10.1021/jp021503p
URIhttp://hdl.handle.net/10261/141172
DOI10.1021/jp021503p
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