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A comparative study of supports for the synthesis of oligonucleotides without using ammonia

AuthorsAviñó, Anna ; Güimil García, Ramón; Díaz, Antonio R.; Albericio, Fernando; Eritja Casadellà, Ramón
KeywordsNucleotide derivative
Drug synthesis
Structure activity relation
Issue Date1996
PublisherMarcel Dekker
CitationNucleosides and Nucleotides 15(11-12): 1871-1889(1996)
AbstractA comparative study of the cleavage efficiency of succinyl, phthaloyl, oxalyl, 2(2-nitrophenyl)ethyl, 9-fluorenylmethyl, and 2-nitrobenzyl supports in 0.5M DBU solutions is described. A decrease in cleavage efficiency is observed when small oligonucleotides containing thymidine are linked to the supports. In these conditions oxalyl supports gave the best yields followed by 2-(2-nitrophenyl)ethyl and 9-fluorenylmethyl supports.
Publisher version (URL)http://dx.doi.org/10.1080/07328319608002739
Appears in Collections:(IQAC) Artículos
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