English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/141171
Share/Impact:
Statistics
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE
Exportar a otros formatos:

Title

A comparative study of supports for the synthesis of oligonucleotides without using ammonia

AuthorsAviñó, Anna ; Güimil García, Ramón; Díaz, Antonio R.; Albericio, Fernando; Eritja Casadellà, Ramón
KeywordsNucleotide derivative
Oligonucleotides
Drug synthesis
Structure activity relation
Issue Date1996
PublisherMarcel Dekker
CitationNucleosides and Nucleotides 15(11-12): 1871-1889(1996)
AbstractA comparative study of the cleavage efficiency of succinyl, phthaloyl, oxalyl, 2(2-nitrophenyl)ethyl, 9-fluorenylmethyl, and 2-nitrobenzyl supports in 0.5M DBU solutions is described. A decrease in cleavage efficiency is observed when small oligonucleotides containing thymidine are linked to the supports. In these conditions oxalyl supports gave the best yields followed by 2-(2-nitrophenyl)ethyl and 9-fluorenylmethyl supports.
Publisher version (URL)http://dx.doi.org/10.1080/07328319608002739
URIhttp://hdl.handle.net/10261/141171
DOIhttp://dx.doi.org/10.1080/07328319608002739
ISSN07328311
Appears in Collections:(IQAC) Artículos
Files in This Item:
File Description SizeFormat 
Avinyo1996NNAN.pdf215,65 kBAdobe PDFThumbnail
View/Open
Show full item record
Review this work
 


WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.