English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/14086
Share/Impact:
Statistics
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:

DC FieldValueLanguage
dc.contributor.authorDelgado, Pilar-
dc.contributor.authorCubelos, Beatriz-
dc.contributor.authorCalleja, Enrique-
dc.contributor.authorMartínez-Martín, Nuria-
dc.contributor.authorCiprés, Ángel-
dc.contributor.authorMérida, Isabel-
dc.contributor.authorBustelo, Xosé R.-
dc.contributor.authorAlarcón, Balbino-
dc.date.accessioned2009-06-29T16:55:48Z-
dc.date.available2009-06-29T16:55:48Z-
dc.date.issued2009-06-28-
dc.identifier.citationNature Immunology (2009), doi: 10.1038/ni.1749 (In press)en_US
dc.identifier.issn1529-2908-
dc.identifier.urihttp://hdl.handle.net/10261/14086-
dc.description10 pages, 7 figures.-- Article in press.en_US
dc.descriptionSupporting information available at: http://www.nature.com/ni/journal/vaop/ncurrent/suppinfo/ni.1749_S1.html-
dc.description.abstractT cell antigen receptors (TCRs) and B cell antigen receptors (BCRs) transmit low-grade signals necessary for the survival and maintenance of mature cell pools. We show here that TC21, a small GTPase encoded by Rras2, interacted constitutively with both kinds of receptors. Expression of a dominant negative TC21 mutant in T cells produced a rapid decrease in cell viability, and Rras2-/- mice were lymphopenic, possibly as a result of diminished homeostatic proliferation and impaired T cell and B cell survival. In contrast, TC21 was overexpressed in several human lymphoid malignancies. Finally, the p110 catalytic subunit of phosphatidylinositol-3-OH kinase (PI(3)K) was recruited to the TCR and BCR in a TC21-dependent way. Consequently, we propose TC21 directly links antigen receptors to PI(3)K-mediated survival pathways.en_US
dc.description.sponsorshipSupported by the Comisión Interministerial de Ciencia y Tecnología (SAF2006-01391), Comunidad de Madrid (SAL-0159/2006), Redes Temáticas de Investigación Cooperativa en Salud (RD06/0020/1002), the Junta de Ampliación de Estudios-doc 2008 program (B.C.) and Fundación Ramón Areces (to the Centro de Biología Molecular Severo Ochoa).en_US
dc.format.extent46625 bytes-
dc.format.mimetypeapplication/pdf-
dc.language.isoengen_US
dc.publisherNature Publishing Groupen_US
dc.rightsclosedAccessen_US
dc.titleEssential function for the GTPase TC21 in homeostatic antigen receptor signalingen_US
dc.typeartículoen_US
dc.identifier.doi10.1038/ni.1749-
dc.description.peerreviewedPeer revieweden_US
dc.relation.publisherversionhttp://dx.doi.org/10.1038/ni.1749en_US
dc.identifier.e-issn1529-2916-
dc.contributor.funderComisión Interministerial de Ciencia y Tecnología, CICYT (España)-
dc.contributor.funderComunidad de Madrid-
dc.contributor.funderInstituto de Salud Carlos III-
dc.contributor.funderFundación Ramón Areces-
dc.identifier.funderhttp://dx.doi.org/10.13039/501100007273es_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/501100004587es_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/100008054es_ES
Appears in Collections:(CBM) Artículos
(CNB) Artículos
(IBMCC) Artículos
Files in This Item:
There are no files associated with this item.
Show simple item record
 

Related articles:


WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.