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Título

T-cell intracellular antigens in health and disease

AutorSánchez-Jiménez, Carmen; Izquierdo, José M.
Palabras claveTIAR
gene expression control
proliferation
cell death
Welander
tumorigenesis
embryogenesis
TIA1
Fecha de publicación18-sep-2015
EditorTaylor & Francis
CitaciónCell Cycle 14: 2033- 2043 (2015)
Resumen© 2015 Taylor & Francis Group, LLC. T-cell intracellular antigen 1 (TIA1) and TIA1-related/like protein (TIAR/TIAL1) are 2 proteins discovered in 1991 as components of cytotoxic T lymphocyte granules. They act in the nucleus as regulators of transcription and pre-mRNA splicing. In the cytoplasm, TIA1 and TIAR regulate and/or modulate the location, stability and/or translation of mRNAs. As knowledge of the different genes regulated by these proteins and the cellular/biological programs in which they are involved increases, it is evident that these antigens are key players in human physiology and pathology. This review will discuss the latest developments in the field, with physiopathological relevance, that point to novel roles for these regulators in the molecular and cell biology of higher eukaryotes.
URIhttp://hdl.handle.net/10261/140535
DOI10.1080/15384101.2015.1053668
Identificadoresdoi: 10.1080/15384101.2015.1053668
issn: 1551-4005
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