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Insights on the health benefits of the bioactive compounds of coffee silverskin extract

AutorFernández, B. ; Lezama Quintana, Adriana; Amigo-Benavent, Miryam; Ullate, Mónica ; Herrero, Miguel ; Martín, M. Ángeles ; Mesa, M. Dolores; Castillo, M. Dolores del
Palabras claveCaffeine
Chlorogenic acid
Type 2 diabetes
Metabolism
Coffee silverskin
Bioaccessibility
Fecha de publicación2016
EditorElsevier
CitaciónJournal of Functional Foods 25: 197-207 (2016)
ResumenThe bioaccessibility of chlorogenic acid (CGA) and caffeine in coffee silverskin extracts (CSE) and the contribution of these substances to the prophylactic effect of CSE on the pathogenesis of diabetes have not been reported. This study aimed to evaluate the bioaccessibility, bioavailability and bioactivity of CGA and caffeine alone and in CSE in the pancreas of rats treated with streptozotocin-nicotinamide (type 2 diabetes model). Metabolism of CGA and caffeine started in the gastrointestinal tract due to changes of pH taking place during digestion. Their metabolites protected pancreatic cells against the risk of diabetes. This is the first in vivo study to demonstrate a specific chemo-protective effect of CSE in pancreatic tissue, and this effect may be associated with its antioxidant capacity. Daily administration of CSE, CGA or caffeine 35 d previous to the induction of diabetes significantly reduced (p < 0.05) pancreatic oxidative stress and protein damage.
Versión del editorhttps://doi.org/10.1016/j.jff.2016.06.001
URIhttp://hdl.handle.net/10261/140285
DOI10.1016/j.jff.2016.06.001
Identificadoresdoi: 10.1016/j.jff.2016.06.001
issn: 1756-4646
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