Por favor, use este identificador para citar o enlazar a este item: http://hdl.handle.net/10261/140268
COMPARTIR / EXPORTAR:
logo share SHARE BASE
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE

Invitar a revisión por pares abierta
Campo DC Valor Lengua/Idioma
dc.contributor.authorVergara, Cristina-
dc.contributor.authorOrdóñez-Gutiérrez, Lara-
dc.contributor.authorWandosell, Francisco-
dc.contributor.authorFerrer, I. M-
dc.contributor.authorRío, José Antonio del-
dc.contributor.authorGavín, Rosalina-
dc.date.accessioned2016-11-16T09:09:49Z-
dc.date.available2016-11-16T09:09:49Z-
dc.date.issued2014-06-26-
dc.identifierdoi: 10.1007/s12035-014-8793-7-
dc.identifierissn: 0893-7648-
dc.identifier.citationMolecular Neurobiology 51: 1206- 1220 (2015)-
dc.identifier.urihttp://hdl.handle.net/10261/140268-
dc.description.abstractSpringer Science+Business Media New York 2014 Abstract Alzheimer’s disease (AD) is characterized by the presence of amyloid plaques mainly consisting of hydrophobic β-amyloid peptide (Aβ) aggregates and neurofibrillary tangles (NFTs) composed principally of hyperphosphorylated tau.Aβ oligomers have been described as the earliest effectors to negatively affect synaptic structure and plasticity in the affected brains, and cellular prion protein (PrPC) has been proposed as receptor for these oligomers. The most widely accepted theory holds that the toxic effects ofAβ are upstream of change in tau, a neuronal microtubule-associated protein that promotes the polymerization and stabilization of microtubules. However, tau is considered decisive for the progression of neurodegeneration, and, indeed, tau pathology-
dc.description.sponsorshipCentro Investigación Biomédica en Red Enfermedades Neurodegenerativas (CIBERNED), Instituto de Salud Carlos III, for the laboratories of IF, JADR and FW. In addition, work in the laboratory of JADR was supported by grants from FP7-PRIORITY and DEMTEST (Joint Programming of Neurodegenerative Diseases, PI11/03028), Ministerio de Economía y Competitividad (MINECO) (BFU2012-32617), Generalitat de Catalunya (SGR2009-366 and SGR2014-1218), and Obra Social “La Caixa”. RG was supported by Fondo de Investigaciones Sanitarias (PI11-00075) and work in FW’s lab was supported by grants from the Direccion General de Ciencia y Tecnologia (DGCYT) (SAF2012-39148-C03-01), and EUFP7-2009-(CT222887), as well as an institutional grant from the ‘Fundación Areces”. CV is supported by the Ministerio de Ciencia e Innovación (MICINN).-
dc.publisherHumana Press-
dc.relation.isversionofPublisher's version-
dc.rightsopenAccess-
dc.subjectAβ oligomers-
dc.subjectCellular prion protein-
dc.subjectAlzheimer’s disease-
dc.subjectMicrotubule-associated protein tau-
dc.titleRole of PrPC Expression in Tau Protein Levels and Phosphorylation in Alzheimer¿s Disease Evolution-
dc.typelibro-
dc.identifier.doi10.1007/s12035-014-8793-7-
dc.date.updated2016-11-16T09:09:50Z-
dc.description.versionPeer Reviewed-
dc.language.rfc3066eng-
dc.contributor.funderMinisterio de Economía y Competitividad (España)-
dc.contributor.funderFundación la Caixa-
dc.contributor.funderInstituto de Salud Carlos III-
dc.contributor.funderFundación Ramón Areces-
dc.contributor.funderMinisterio de Ciencia e Innovación (España)-
dc.contributor.funderInstituto de Salud Carlos III-
dc.contributor.funderCentro Investigación Biomédica en Red Enfermedades Neurodegenerativas (España)-
dc.contributor.funderGeneralitat de Catalunya-
dc.contributor.funderEuropean Commission-
dc.relation.csic-
dc.identifier.funderhttp://dx.doi.org/10.13039/501100003329es_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/100008054es_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/501100004837es_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/501100004587es_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/501100002809es_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/501100000780es_ES
dc.type.coarhttp://purl.org/coar/resource_type/c_2f33es_ES
item.openairetypelibro-
item.cerifentitytypePublications-
item.grantfulltextopen-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.fulltextWith Fulltext-
Aparece en las colecciones: (CBM) Artículos
Ficheros en este ítem:
Fichero Descripción Tamaño Formato
Wandosell F Role of PrPC.pdf1,8 MBAdobe PDFVista previa
Visualizar/Abrir
Show simple item record

CORE Recommender

Page view(s)

211
checked on 27-mar-2024

Download(s)

284
checked on 27-mar-2024

Google ScholarTM

Check

Altmetric

Altmetric


NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.