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dc.contributor.author | Vergara, Cristina | - |
dc.contributor.author | Ordóñez-Gutiérrez, Lara | - |
dc.contributor.author | Wandosell, Francisco | - |
dc.contributor.author | Ferrer, I. M | - |
dc.contributor.author | Río, José Antonio del | - |
dc.contributor.author | Gavín, Rosalina | - |
dc.date.accessioned | 2016-11-16T09:09:49Z | - |
dc.date.available | 2016-11-16T09:09:49Z | - |
dc.date.issued | 2014-06-26 | - |
dc.identifier | doi: 10.1007/s12035-014-8793-7 | - |
dc.identifier | issn: 0893-7648 | - |
dc.identifier.citation | Molecular Neurobiology 51: 1206- 1220 (2015) | - |
dc.identifier.uri | http://hdl.handle.net/10261/140268 | - |
dc.description.abstract | Springer Science+Business Media New York 2014 Abstract Alzheimer’s disease (AD) is characterized by the presence of amyloid plaques mainly consisting of hydrophobic β-amyloid peptide (Aβ) aggregates and neurofibrillary tangles (NFTs) composed principally of hyperphosphorylated tau.Aβ oligomers have been described as the earliest effectors to negatively affect synaptic structure and plasticity in the affected brains, and cellular prion protein (PrPC) has been proposed as receptor for these oligomers. The most widely accepted theory holds that the toxic effects ofAβ are upstream of change in tau, a neuronal microtubule-associated protein that promotes the polymerization and stabilization of microtubules. However, tau is considered decisive for the progression of neurodegeneration, and, indeed, tau pathology | - |
dc.description.sponsorship | Centro Investigación Biomédica en Red Enfermedades Neurodegenerativas (CIBERNED), Instituto de Salud Carlos III, for the laboratories of IF, JADR and FW. In addition, work in the laboratory of JADR was supported by grants from FP7-PRIORITY and DEMTEST (Joint Programming of Neurodegenerative Diseases, PI11/03028), Ministerio de Economía y Competitividad (MINECO) (BFU2012-32617), Generalitat de Catalunya (SGR2009-366 and SGR2014-1218), and Obra Social “La Caixa”. RG was supported by Fondo de Investigaciones Sanitarias (PI11-00075) and work in FW’s lab was supported by grants from the Direccion General de Ciencia y Tecnologia (DGCYT) (SAF2012-39148-C03-01), and EUFP7-2009-(CT222887), as well as an institutional grant from the ‘Fundación Areces”. CV is supported by the Ministerio de Ciencia e Innovación (MICINN). | - |
dc.publisher | Humana Press | - |
dc.relation.isversionof | Publisher's version | - |
dc.rights | openAccess | - |
dc.subject | Aβ oligomers | - |
dc.subject | Cellular prion protein | - |
dc.subject | Alzheimer’s disease | - |
dc.subject | Microtubule-associated protein tau | - |
dc.title | Role of PrPC Expression in Tau Protein Levels and Phosphorylation in Alzheimer¿s Disease Evolution | - |
dc.type | libro | - |
dc.identifier.doi | 10.1007/s12035-014-8793-7 | - |
dc.date.updated | 2016-11-16T09:09:50Z | - |
dc.description.version | Peer Reviewed | - |
dc.language.rfc3066 | eng | - |
dc.contributor.funder | Ministerio de Economía y Competitividad (España) | - |
dc.contributor.funder | Fundación la Caixa | - |
dc.contributor.funder | Instituto de Salud Carlos III | - |
dc.contributor.funder | Fundación Ramón Areces | - |
dc.contributor.funder | Ministerio de Ciencia e Innovación (España) | - |
dc.contributor.funder | Instituto de Salud Carlos III | - |
dc.contributor.funder | Centro Investigación Biomédica en Red Enfermedades Neurodegenerativas (España) | - |
dc.contributor.funder | Generalitat de Catalunya | - |
dc.contributor.funder | European Commission | - |
dc.relation.csic | Sí | - |
dc.identifier.funder | http://dx.doi.org/10.13039/501100003329 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/100008054 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100004837 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100004587 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100002809 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100000780 | es_ES |
dc.type.coar | http://purl.org/coar/resource_type/c_2f33 | es_ES |
item.openairetype | libro | - |
item.cerifentitytype | Publications | - |
item.grantfulltext | open | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.fulltext | With Fulltext | - |
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Fichero | Descripción | Tamaño | Formato | |
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Wandosell F Role of PrPC.pdf | 1,8 MB | Adobe PDF | Visualizar/Abrir |
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