English   español  
Por favor, use este identificador para citar o enlazar a este item: http://hdl.handle.net/10261/140268
Título

Role of PrPC Expression in Tau Protein Levels and Phosphorylation in Alzheimer¿s Disease Evolution

AutorVergara, Cristina; Ordóñez-Gutiérrez, Lara; Wandosell, Francisco; Ferrer, I. M; Río, J. A. del; Gavín, Rosalina
Palabras claveAβ oligomers
Cellular prion protein
Alzheimer’s disease
Microtubule-associated protein tau
Fecha de publicación26-jun-2014
EditorHumana Press
CitaciónMolecular Neurobiology 51: 1206- 1220 (2015)
ResumenSpringer Science+Business Media New York 2014 Abstract Alzheimer’s disease (AD) is characterized by the presence of amyloid plaques mainly consisting of hydrophobic β-amyloid peptide (Aβ) aggregates and neurofibrillary tangles (NFTs) composed principally of hyperphosphorylated tau.Aβ oligomers have been described as the earliest effectors to negatively affect synaptic structure and plasticity in the affected brains, and cellular prion protein (PrPC) has been proposed as receptor for these oligomers. The most widely accepted theory holds that the toxic effects ofAβ are upstream of change in tau, a neuronal microtubule-associated protein that promotes the polymerization and stabilization of microtubules. However, tau is considered decisive for the progression of neurodegeneration, and, indeed, tau pathology
URIhttp://hdl.handle.net/10261/140268
DOI10.1007/s12035-014-8793-7
Identificadoresdoi: 10.1007/s12035-014-8793-7
issn: 0893-7648
Aparece en las colecciones: (CBM) Artículos
Ficheros en este ítem:
Fichero Descripción Tamaño Formato  
Wandosell F Role of PrPC.pdf1,8 MBAdobe PDFVista previa
Visualizar/Abrir
Mostrar el registro completo
 

Artículos relacionados:


NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.