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Título

Role of AGC1/aralar in the metabolic synergies between neuron and glia

AutorContreras, Laura
Palabras claveGlutamine
Aspartate
Neuron
Astrocyte
Metabolism
Aralar
Fecha de publicación15-abr-2015
EditorElsevier
CitaciónNeurochemistry International 88: 38- 46 (2015)
Resumen© 2015 Elsevier Ltd. Brain energetic requirements are elevated due to the high cost of impulse transmission and information storage, and are met mainly by glucose oxidation. The energy needs are closely matched by metabolic regulation, which requires the close cooperation of neurons and astrocytes and involves highly regulated fluxes of metabolites between cells. The metabolism in each type of cell is determined in part by its proteomic profile, which has been regarded as complementary. This review will consider the cellular distribution of the mitochondrial aspartate-glutamate carrier, aralar/AGC1/SLC25A12, and its role in the synergic metabolism between neurons and astrocytes.
URIhttp://hdl.handle.net/10261/140265
DOI10.1016/j.neuint.2015.04.001
Identificadoresdoi: 10.1016/j.neuint.2015.04.001
issn: 1872-9754
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