English   español  
Por favor, use este identificador para citar o enlazar a este item: http://hdl.handle.net/10261/140236
COMPARTIR / IMPACTO:
Estadísticas
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:
Título

Reconciling west nile virus with the autophagic pathway

AutorMartín-Acebes, Miguel Ángel; Blázquez, Ana Belén; Saiz, Juan-Carlos
Palabras claveautophagy
West Nile virus (WNV)
infection
LC3
mutants
virus strain
flavivirus
Fecha de publicación2015
EditorTaylor & Francis
CitaciónAutophagy 11: 861- 864 (2015)
Resumen© 2015, Taylor & Francis Group, LLC. West Nile virus (WNV) is a neurotropic mosquito-borne flavivirus responsible for recurrent outbreaks of meningitis and encephalitis. Several studies analyzing the interactions of this pathogen with the autophagic pathway have reported opposite results with evidence for and against the upregulation of autophagy in infected cells. In this regard, we have recently reported that minimal genetic changes (single amino acid substitutions) in nonstructural proteins of WNV can modify the ability of the virus to induce autophagic features such as LC3 modification and aggregation in infected cells. We think that these results could help explain some of the previously reported discrepancies. These findings could also aid in deciphering the interactions of this pathogen with the autophagic pathway at the molecular level aimed to develop feasible antiviral strategies to combat this pathogen, and other related flaviviruses.
URIhttp://hdl.handle.net/10261/140236
DOI10.1080/15548627.2015.1037062
Identificadoresdoi: 10.1080/15548627.2015.1037062
issn: 1554-8635
Aparece en las colecciones: (CBM) Artículos
Ficheros en este ítem:
Fichero Descripción Tamaño Formato  
Martín-AcebesMA_ReconcilingWestNileVirus.pdf65,28 kBAdobe PDFVista previa
Visualizar/Abrir
Mostrar el registro completo
 

Artículos relacionados:


NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.