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Título

Venomic Analysis of the Poorly Studied Desert Coral Snake, Micrurus tschudii tschudii, Supports the 3FTx/PLA₂ Dichotomy across Micrurus Venoms

AutorSanz, Libia ; Pla, Davinia ; Pérez, Alicia ; Rodríguez, Yania; Zavaleta, Alfonso; Salas, María; Lomonte, Bruno; Calvete, Juan J.
Palabras claveMicrurus tschudii tschudii venom
Venomics
Snake venom proteome
Three-finger toxin
Snake venom phospholipase A2
Mass spectrometry
Fecha de publicación7-jun-2016
EditorMolecular Diversity Preservation International
CitaciónToxins; 8(6): E178 (2016)
ResumenThe venom proteome of the poorly studied desert coral snake Micrurus tschudii tschudii was unveiled using a venomic approach, which identified ≥38 proteins belonging to only four snake venom protein families. The three-finger toxins (3FTxs) constitute, both in number of isoforms (~30) and total abundance (93.6% of the venom proteome), the major protein family of the desert coral snake venom. Phospholipases A₂ (PLA₂s; seven isoforms, 4.1% of the venom proteome), 1-3 Kunitz-type proteins (1.6%), and 1-2 l-amino acid oxidases (LAO, 0.7%) complete the toxin arsenal of M. t. tschudii. Our results add to the growing evidence that the occurrence of two divergent venom phenotypes, i.e., 3FTx- and PLA₂-predominant venom proteomes, may constitute a general trend across the cladogenesis of Micrurus. The occurrence of a similar pattern of venom phenotypic variability among true sea snake (Hydrophiinae) venoms suggests that the 3FTx/PLA₂ dichotomy may be widely distributed among Elapidae venoms.
DescripciónArtículo electrónico,12 páginas, 2 figuras, 1 tabla. Material suplementario en: http://www.mdpi.com/2072-6651/8/6/178#supplementary
Versión del editorhttp://dx.doi.org/10.3390/toxins8060178
URIhttp://hdl.handle.net/10261/139966
DOI10.3390/toxins8060178
E-ISSN2072-6651
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