English   español  
Por favor, use este identificador para citar o enlazar a este item: http://hdl.handle.net/10261/139963
COMPARTIR / IMPACTO:
Estadísticas
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:
Título

Insights into the Evolution of a Snake Venom Multi-Gene Family from the Genomic Organization of Echis ocellatus SVMP Genes

AutorSanz, Libia ; Calvete, Juan J.
Palabras claveSnake venom toxin multi-gene family
Snake venom metalloproteinase
genomic organization of SVMP genes
PII-SVMP
PI-SVMP
Gene duplication; intronic retroelements
Intronization
Fecha de publicación12-jul-2016
EditorMolecular Diversity Preservation International
CitaciónToxins; 8(7). pii: E216 (2016)
ResumenThe molecular events underlying the evolution of the Snake Venom Metalloproteinase (SVMP) family from an A Disintegrin And Metalloproteinase (ADAM) ancestor remain poorly understood. Comparative genomics may provide decisive information to reconstruct the evolutionary history of this multi-locus toxin family. Here, we report the genomic organization of Echis ocellatus genes encoding SVMPs from the PII and PI classes. Comparisons between them and between these genes and the genomic structures of Anolis carolinensis ADAM28 and E. ocellatus PIII-SVMP EOC00089 suggest that insertions and deletions of intronic regions played key roles along the evolutionary pathway that shaped the current diversity within the multi-locus SVMP gene family. In particular, our data suggest that emergence of EOC00028-like PI-SVMP from an ancestral PII(e/d)-type SVMP involved splicing site mutations that abolished both the 3' splice AG acceptor site of intron 12* and the 5' splice GT donor site of intron 13*, and resulted in the intronization of exon 13* and the consequent destruction of the structural integrity of the PII-SVMP characteristic disintegrin domain.
Descripciónartículo electrónico, 32 páginas, 7 figuras (dos de ellas como material suplementario, 2 tablas
Versión del editorhttp://de.doi.org/10.3390/toxins8070216
URIhttp://hdl.handle.net/10261/139963
DOI10.3390/toxins8070216
E-ISSN2072-6651
Aparece en las colecciones: (IBV) Artículos
Ficheros en este ítem:
Fichero Descripción Tamaño Formato  
2016 Toxins 008-00216.pdf6,66 MBAdobe PDFVista previa
Visualizar/Abrir
Mostrar el registro completo
 

Artículos relacionados:


NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.