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Title

New delivery systems for amphotericin B applied to the improvement of leishmaniasis treatment

AuthorsChávez-Fumagalli, Miguel A.; Soto, Manuel ; Ferraz Coelho, Eduardo Antonio
KeywordsNanoparticles
Toxicity
Treatment
Lipid-based formulations
Amphotericin B
Leishmaniasis
Issue Date2015
PublisherSociedade Brasileira de Medicina Tropical
CitationRevista da Sociedade Brasileira de Medicina Tropical 48: 235- 242 (2015)
Abstract© 2015, Sociedade Brasileira de Medicina Tropical. All rights reserved. Leishmaniasis is one of the six major tropical diseases targeted by the World Health Organization. It is a life-threatening disease of medical, social and economic importance in endemic areas. No vaccine is yet available for human use, and chemotherapy presents several problems. Pentavalent antimonials have been the drugs of choice to treat the disease for more than six decades; however, they exhibit high toxicity and are not indicated for children, for pregnant or breastfeeding women or for chronically ill patients. Amphotericin B (AmpB) is a second-line drug, and although it has been increasingly used to treat visceral leishmaniasis (VL), its clinical use has been hampered due to its high toxicity. This review focuses on the development and in vivo usage of new delivery systems for AmpB that aim to decrease its toxicity without altering its therapeutic efficacy. These new formulations, when adjusted with regard to their production costs, may be considered new drug delivery systems that promise to improve the treatment of leishmaniasis, by reducing the side effects and the number of doses while permitting a satisfactory cost-benefit ratio.
URIhttp://hdl.handle.net/10261/139947
DOI10.1590/0037-8682-0138-2015
Identifiersdoi: 10.1590/0037-8682-0138-2015
issn: 0037-8682
Appears in Collections:(CBM) Artículos
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