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Por favor, use este identificador para citar o enlazar a este item: http://hdl.handle.net/10261/1398

ACRATA: a novel electron transfer domain associated to apoptosis and cancer

AutorSánchez-Pulido, Luis; Rojas, A. M. ; Valencia, Alfonso; Martínez-Alonso, Carlos; Andrade, Miguel A.
Fecha de publicación19-dic-2004
EditorBioMed Central
CitaciónBMC Cancer 498: 98 (2004)
Resumen[Background] Recently, several members of a vertebrate protein family containing a six trans-membrane (6TM) domain and involved in apoptosis and cancer (e.g. STEAP, STAMP1, TSAP6), have been identified in Golgi and cytoplasmic membranes. The exact function of these proteins remains unknown.
[Methods] We related this 6TM domain to distant protein families using intermediate sequences and methods of iterative profile sequence similarity search.
[Results] Here we show for the first time that this 6TM domain is homolog to the 6TM heme binding domain of both the NADPH oxidase (Nox) family and the YedZ family of bacterial oxidoreductases.
[Conclusions] This finding gives novel insights about the existence of a previously undetected electron transfer system involved in apoptosis and cancer, and suggests further steps in the experimental characterization of these evolutionarily related families.
Versión del editorhttp://dx.doi.org/10.1186/1471-2407-4-98
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